AKTIVITAS ANTIINFLAMASI SENYAWA AKTIF DAUN JAWER KOTOK (Plectranthus scutellarioides (L.)R.Br.) MELALUI INHIBISI Siklooksigenase-2 SECARA IN SILICO

Alya Rizqi Maharani; Rini Madyastuti Purwono; Riki Siswandi; Dona Astari; Farhamzah

doi:10.36805/jbf.v5i1.1343

Alya Rizqi Maharani Mahasiswa Program Sarjana Sekolah Kedokteran Hewan dan Sain Biomedis, IPB University
Rini Madyastuti Purwono Staff Sub Divisi Farmasi Veteriner, Sekolah Kedokteran Hewan dan Sains Biomedis, IPB University
Riki Siswandi Staff Divisi Bedah dan Radiologi Sekolah Kedokteran Hewan dan Sains Biomedis, IPB University
Dona Astari Staff Sub Divisi Farmasi Veteriner, Sekolah Kedokteran Hewan dan Sains Biomedis, IPB University
Farhamzah Program Studi Farmasi, Fakultas Farmasi, Universitas Buana Perjuangan Karawang, Jawa Barat

DOI: https://doi.org/10.36805/jbf.v5i1.1343

Kata Kunci: Jawer kotok, Plectranthus scutellarioides (L.)R.Br, In silico, COX-2, antiinflamasi

Abstrak

Inflamasi merupakan respon tubuh apabila ada paparan yang berbahaya dalam upaya meningkatkan imunitas. Inflamasi yang tidak ditangani dengan baik dapat menyebabkan penyakit degeratif . Tujuan penelitian ini adalah menganalisi potensi daun jawer kotok sebagai anti inflamasi. Penelitian ini menggunakan metode insilico molecular docking dengan bahan ligan uji merupakan senyawa aktif dari daun jawer kotok dan reseptor target COX-2. Hasil penelitian menunjukkan ligan uji Antosianin menunjukkan interaksi terbaik sebagai inhibitor reseptor target yang ditunjukkan dengan nilai energi afinitas terbaik dibanding ligan uji lainnya

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