AKTIVITAS ANTIINFLAMASI SENYAWA AKTIF DAUN JAWER KOTOK (Plectranthus scutellarioides (L.)R.Br.) MELALUI INHIBISI Siklooksigenase-2 SECARA IN SILICO

Alya Rizqi Maharani; Rini Madyastuti Purwono; Riki Siswandi; Dona Astari Nurkarimah; Farhamzah

doi:10.36805/jbf.v5i1.1343

Alya Rizqi Maharani Mahasiswa Program Sarjana Sekolah Kedokteran Hewan dan Sain Biomedis, IPB University
Rini Madyastuti Purwono Staff Sub Divisi Farmasi Veteriner, Sekolah Kedokteran Hewan dan Sains Biomedis, IPB University
Riki Siswandi Staff Divisi Bedah dan Radiologi Sekolah Kedokteran Hewan dan Sains Biomedis, IPB University
Dona Astari Nurkarimah Staff Sub Divisi Farmasi Veteriner, Sekolah Kedokteran Hewan dan Sains Biomedis, IPB University
Farhamzah Program Studi Farmasi, Fakultas Farmasi, Universitas Buana Perjuangan Karawang, Jawa Barat

DOI: https://doi.org/10.36805/jbf.v5i1.1343

Keywords: Jawer kotok, Plectranthus scutellarioides (L.)R.Br, In silico, COX-2, antiinflammation

Abstract

Inflammation is the body’s response to harmful stimuli, and it plays a crucial role in boosting immunity. However, if inflammation is not managed properly, it can lead to degenerative diseases. This research aims to analyze the potential of Plectranthus scutellarioides (L.) R. Br. leaves as an anti-inflammatory agent. The study employs an in silico molecular docking method, using the active compound from the plant as the test ligand and the COX-2 receptor as the target. The results indicate that the test ligand, Antosianin, shows the best interaction as an inhibitor of the target receptor, as demonstrated by its superior affinity energy value compared to the other test ligands.

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