FORMULASI SEDIAAN MASKER GEL PEEL OFF EKSTRAK DAUN SIRIH CINA (PEPEROMIA PELLUCIDA)

  • Nurul Mawaddah Nasution Bachelor of Clinical Pharmacy, Faculty of Health Sciences, Universitas Prima Indonesia, Medan, 20118 , Indonesia
  • Astriani Natalia Br Ginting Department of Clinical Pharmacy, Faculty of Health Sciences, Universitas Prima Indonesia, Medan, , 20118 , Indonesia
  • Muhammad Yunus PUI Phyto Degenerative & Lifestyle Medicine, Universitas Prima Indonesia
Keywords: Chinese betel leaf, Peperomia pellucida, peel-off gel mask, antibacterial, cosmetic formulation

Abstract

Acne vulgaris is a common skin disorder often associated with increased sebum production and colonization of Cutibacterium acnes on the skin. Peperomia pellucida L. is a medicinal plant known to contain secondary metabolites such as flavonoids, alkaloids, saponins, and tannins, which have potential for use in the development of natural cosmetic formulations. This study aimed to formulate Peperomia pellucida leaf extract into a peel-off gel mask preparation and evaluate its physical characteristics. The extraction of the leaves was carried out using a maceration method with 96% ethanol as the solvent. The obtained extract was then formulated into four different concentrations (0%, 2%, 4%, and 6%) using a gel base consisting of polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), triethanolamine (TEA), glycerin, nipagin, nipasol, and distilled water. The evaluation of the formulations included organoleptic observation, homogeneity test, pH measurement, drying time, and spreadability test. The results showed that all formulations produced homogeneous preparations with pH values ranging from 5.75 to 6.20, drying time between 15–25 minutes, and spreadability ranging from 6.3 to 6.8 cm. Increasing extract concentration affected the organoleptic characteristics and drying time of the preparations. Based on the physical evaluation results, the formulation containing 4% extract demonstrated the most optimal physical characteristics compared with the other formulations.

References

Fatha, N., Umar, A., & Mursyid, M. (2023). Formulasi sediaan anti acne masker gel peel-off ekstrak suruhan (Peperomia pellucida). Jurnal Farmasi Higea, 15(2), 100–106.

Ginting, A. N. B., Ginting, C. N., Rusip, G., & Chiuman, L. (2025). Aktivitas antidiabetik nanopartikel ekstrak daun cep-cepan (Castanopsis costata) pada model tikus putih yang diinduksi streptozotocin. Jurnal Penelitian Pendidikan IPA, 11(2), 64–70. https://doi.org/10.29303/jppipa.v11i2.9408

Ginting, A. N. B., Kaban, V. E., Bangar, R. I., & Harahap, D. W. S. (2025).Formulasi dan uji aktivitas antibakteri gel minyak atsiri rimpang lengkuas merah (Alpinia purpurata K. Schum) terhadap Propionibacterium acnes.INSOLOGI: Jurnal Sains dan Teknologi, 4(1), 75–88.https://doi.org/10.55123/insologi.v4i1.4844

Harefa, H. E. E., Ginting, A. N. B., Meutia, R., & Simanjuntak, N. J. P. (2025).Uji aktivitas ekstrak salam (Syzygium polyanthum) pada diabetes penyakit yang disebabkan dengan tikus putih (Rattus norvegicus).Jurnal Sains Farmasi dan Kesehatan, 3(1),17.https://jurnal.ittc.web.id/index.php/jibs/index

Indra, I., Prawira, Y. A., & Setiawan, F. (2025).Pengembangan dan evaluasi masker gel peel-off Peperomia pellucida L. sebagai agen anti-jerawat.Pharmacoscript, 8(1), 79–95.https://doi.org/10.36423/pharmacoscript.v8i1.2025

Keliat, E. N. Q. P., Yunus, M., & Sembiring, N. B. (2024). Uji efektivitas ekstrak daun sukun (Artocarpus altilis) sebagai penurunan kadar glukosa darah yang diinduksi aloksan terhadap tikus jantan putih (Rattus norvegicus) dan uji antioksidan ekstrak daun sukun. Jurnal Kesehatan Tambusai, 5(3), 7583–7590.

Natalia, A., Karolina, H., Meutia, R., & Lubis, A. A. (2025).Effectiveness of kersen leaf(Muntingia calabura L.) extract on rats as an anti-diabetic agent.In E. Fachrial & S.Suhartomi (Eds.), Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024) (Advances in Health Sciences Research, Vol. 84, pp. 284–294). Atlantis Press.https://doi.org/10.2991/978-94-6463-664-2_26

Marpaung, C. E. L., Rusip, H. G., & Juli, N. (2024). Formulasi sediaan masker gel dari ekstrak etanol buah labu kuning (Cucurbita moschata Durch). Jurnal Kesehatan Tambusai, 5(3), 6780–6786.

Nofal, A. M. K., Elhawary, E. E., Ashour, D. S., & Abdel-Latif, A. M. (2025).Terapi cahaya excimer dan gel adapalene/benzoyl peroxide topikal dalam pengobatan jerawat vulgaris. Egyptian Journal of Hospital Medicine, 98, 289–292.https://ejhm.journals.ekb.eg

Permadani, A., Nikmah, H., Halimatussakdiah, H., Mastura, M., & Amna, U. (2024).Skrining fitokimia daun sirih cina (Peperomia pellucida L.) dari Kecamatan Birem Bayeun, Aceh Timur.Quimica: Jurnal Kimia Sains dan Terapan, 6(1), 6–12.https://ejurnalunsam.id/index.php/JQ

Purwoko, M. L. Y., Syamsudin, & Simanjuntak, P. (2020).Standardisasi parameter spesifik dan nonspesifik ekstrak etanol daun kelor (Moringa oleifera) asal Kabupaten Blora.Sainstech Farma, 13(2), 124–129

Raju, T., Shamly, R. A. C., Nasrin, H., Safwan, M., Devanand, P. O., & Prasanth, M. L. (2022). Design, formulation and optimization of peel-off face mask gel for the symptomatic treatment of rosacea. Journal of Pharmaceutical Research Science & Technology, 6(2), 164. https://doi.org/10.31531/jprst.1000164

Razoki., & Lister, I. N. (2025). Aktivitas farmakologi dan potensi bioaktif daun sirih cina (Peperomia pellucida L. (Kunth.)). Journal of Pharmaceutical and Sciences, 8(3), 2088–2097. https://doi.org/10.36490/journal-jps.com.v8i3.1000

Sitanggang, T. K., Yunus, M., & Ginting, A. N. B. (2025). Formulasi dan evaluasi sediaan krim ekstrak daun alpukat (Persea americana Mill.). Jurnal Farmasi dan Klinis Nusantara, 3(2), 75–80. https://doi.org/10.58549/pcjn.v3i02.106

Vasam, M., Korutla, S., & Bohara, R. A. (2023). Acne vulgaris: A review on pathophysiology, treatment, and recent advances based on nanotechnology. Biochemistry and Biophysics Reports, 36, 101578.https://doi.org/10.1016/j.bbrep.2023.101578

Yunus, M., Naldi, J., & Andry, M. (2023). Uji aktivitas diuretik ekstrak etanol daun sirih merah (Piper crocatum Ruiz & Pav) terhadap tikus putih jantan (Rattus norvegicus). Journal of Pharmaceutical and Sciences, 6(3), 1161–1169.

Published
2026-03-31