AKTIVITAS KANDUNGAN DAUN SIRIH (Piper betle L.) SEBAGAI ANTIOKSIDAN : LITERATURE REVIEW ARTICLE

Himyatul Hidayah; Farhamzah; Surya Amal; Iis Dahlia

doi:10.36805/jbf.v2i3.549

Himyatul Hidayah Fakultas Farmasi, Universitas Buana Perjuangan Karawang, Karawang, Indonesia
Farhamzah Fakultas Farmasi, Universitas Buana Perjuangan Karawang, Karawang, Jawa Barat, Indonesia
Surya Amal Fakultas Farmasi, Universitas Buana Perjuangan Karawang, Karawang, Indonesia
Iis Dahlia Fakultas Farmasi, Universitas Buana Perjuangan Karawang, Karawang, Indonesia

DOI: https://doi.org/10.36805/jbf.v2i3.549

Keywords: Antioxidant, Literature Review, Piper betle L.

Abstract

Antioxidants are compounds that can inhibit the oxidation of lipids or other molecules by inhibiting the initiation or propagation of chain oxidation reactions. Exogenous antioxidants consist of natural antioxidants and synthetic antioxidants. Concerns about the side effects of using synthetic antioxidants that can increase carcinogenesis have encouraged the use of natural antioxidants as an alternative source of antioxidants. One source of natural antioxidants can be obtained from plant species that contain antioxidants, namely those from Piper betle L. This literature review article aims to determine the content of Piper betle L. betel leaf as an antioxidant. The literature search process used is Google Scholar, PubMet and Science Direct published in 2011-2021. And the search results found 12 articles with each article stating that Piper betle L. Has antioxidant activity which is included in the category of very strong IC50 values. This is because betel contains quercetin, phenolic compounds, chlorogenic acid, atoxin, eugenol and gallic acid

References

Abrahim, Noor N., M. S. Kanthimathi, and Azlina Abdul-Aziz. 2012. “Piper Betle Shows Antioxidant Activities, Inhibits MCF-7 Cell Proliferation and Increases Activities of Catalase and Superoxide Dismutase.” BMC Complementary and Alternative Medicine 12. https://doi.org/10.1186/1472-6882-12-220.

Agusta, A. 2015. “Minyak Atsiri Tumbuhan Tropika Indonesia.” Institute Teknologi Bandung.

Alam, Badrul, Fahima Akter, Nahida Parvin, Rashna Sharmin Pia, Sharmin Akter, Jesmin Chowdhury, Kazi Sifath-E-Jahan, and Ekramul Haque. 2013. “Antioxidant, Analgesic and Anti-Inflammatory Activities of the Methanolic Extract of Piper betle Leaves.” Avicenna Journal of Phytomedicine 3 (2): 112–25. https://doi.org/10.22038/ajp.2013.16.

Arif, Widya. 2020. Uji Daya Hambat Air Rebusan Daun Sirih Hijau (Piper Betle L.) Terhadap Pertumbuhan Jamur Candida Albicans.

Denney, A., S, and R. Tewksbury. 2013. “How To Write a Literature.” Journal Of Criminal Justice Education 24 (2): 218–34.

Fitria, S., W. Susi, and P. W Ire. 2016. “Rancangan Program Aplikasi Informasi Ramuan Etnomedisin Obat Tradisional Indonesia Berbasis Android.” Jurnal Ilmiah Komputasi 15 (1): 71–80.

Inayatullah, Seila. 2012. “Efek Ekstrak Daun Sirih Hijau (Piper betle L.) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus,” 50.

Jaiswal, S G, M Patel, D K Saxena, and Di Matteo. 2014. “Sifat Antioksidan Dari Sirih Piper ( L ) Ekstrak Daun Dari Enam Domain Geografis” 1: 18–26.

Kavitha, S., and Parthasarathi Perumal. 2018. “Antidiabetic and Antioxidant Activities of Ethanolic Extract of Piper Betle l. Leaves in Catfish, Clarias Gariepinus.” Asian Journal of Pharmaceutical and Clinical Research 11 (3): 194–98. https://doi.org/10.22159/ajpcr.2018.v11i3.22393.

Kursia, Sukriani, Julianri S Lebang, Burhanuddin Taebe, Asril Burhan, Wa O.R Rahim, and Nursamsiar. 2016. “Uji Aktivitas Antibakteri Ekstrak Etilasetat Daun Sirih Hijau (Piper Betle L.) Terhadap Bakteri Staphylococcus Epidermidis.” Indonesian Journal of Pharmaceutical Science and Technology 3 (2): 72–77.

Kusumawati, AH., Farhamzah, F., Alkandahri, MY., Sadino, A., Agustina, LS., and Apriana, SD. Antioxidant Activity and Sun Protection Factor of Black Glutinous Rice (Oryza sativa var. glutinosa). Tropical Journal of Natural Product Research. 2021; 5(11): 1958-1961.

Nguyen, Lam Thi Truc, Thuong Thi Nguyen, Hoa Ngoc Nguyen, and Quynh Thi Phuong Bui. 2020. “ Simultaneous Determination of Active Compounds in Piper Betle Linn. Leaf Extract and Effect of Extracting Solvents on Bioactivity .” Engineering Reports 2 (10): 2–9. https://doi.org/10.1002/eng2.12246.

Nouri, Leila, Abdorreza Mohammadi Nafchi, and A. A. Karim. 2014. “Phytochemical, Antioxidant, Antibacterial, and α-Amylase Inhibitory Properties of Different Extracts from Betel Leaves.” Industrial Crops and Products 62: 47–52. https://doi.org/10.1016/j.indcrop.2014.08.015.

Nur Sazwi, Nordin, Thurairajah Nalina, and Zubaidah Haji A. Rahim. 2013. “Antioxidant and Cytoprotective Activities of Piper Betle, Areca Catechu, Uncaria Gambir and Betel Quid with and without Calcium Hydroxide.” BMC Complementary and Alternative Medicine 13. https://doi.org/10.1186/1472-6882-13-351.

Prakash, Bhanu, Ravindra Shukla, Priyanka Singh, Ashok Kumar, Prashant Kumar Mishra, and Nawal Kishore Dubey. 2010. “Efficacy of Chemically Characterized Piper Betle L. Essential Oil against Fungal and Aflatoxin Contamination of Some Edible Commodities and Its Antioxidant Activity.” International Journal of Food Microbiology 142 (1–2): 114–19. https://doi.org/10.1016/j.ijfoodmicro.2010.06.011.

Qonitah, Fadilah, and Ahwan. 2018. “Aktivitas Antioksidan Dan Kandungan Fenolik Total Dari Isolat Polar Fraksi Heksana Ekstrak Etanol Daun Sirih (Piper Betle L.).” Jurnal Farmasetis 7 (2): 42–46. https://doi.org/10.32583/farmasetis.v7i2.382.

R, Ekosari, and Lili Sugiarto. 2013. “Studi Fisiologis Daun Sirih ‘Temurose.’” Jurnal Sains Dasar 2 (1): 7–12. https://doi.org/10.21831/jsd.v2i1.2372.

Rahayu, Titik, Syafrimen Syafril, Ismail Suardi Wekke, and Rita Erlinda. 2015. “Teknik Menulis Review Literatur Dalam Sebuah Artikel Ilmiah” 3 (2): 2015. http://weekly.cnbnews.com/news/article.html?no=124000.

Ramdhani, A;, M. A; Ramdhani, and S. Amin, A. 2014. “Writing a Literature Review Research Paper; A Step-by-Step Approach.” International Journal Of Basic and Aplied Science 03 (01): 47–56.

Risdian, Chandra, Wahyu Widowati, Tjandrawati Mozef, Teresa Liliana Wargasetia, and Khie Khiong. 2011. “Free Radical Scavenging Activity of Ethanolic Leaves Extract and Its Different Solvent Fractions of Piper Betle L. In Vitro.” Indonesian Journal of Cancer Chemoprevention 2 (1): 141. https://doi.org/10.14499/indonesianjcanchemoprev2iss1pp141-145.

Savsani, Hardik, Abhay Srivastava, Sarita Gupta, and Kirti Patel. 2020. “Strengthening Antioxidant Defense & Cardio Protection by Piper Betle: An in-Vitro Study.” Heliyon 6 (1): e03041. https://doi.org/10.1016/j.heliyon.2019.e03041.

Serlahwaty, Diana, Setyorini Sugiastuti, and Rizka Chandra Ningrum. 2011. “Aktivitas Antioksidan Ekstrak Air Dan Etanol 70% Daun Sirih Hijau (Piper Betle L.) Dan Sirih Merah (Piper Cf. Fragile Benth.) Dengan Metode Perendaman Radikal Bebas DPPH.” Jurnal Ilmu Kefarmsian Indonesia 9 (2): 143–46.

Shafirany, MZ., Indawati, I., Sulastri, L., Sadino, A., Kusumawati, AH., and Alkandahri, MY. Antioxidant Activity of Red and Purple Rosella Flower Petals Extract (Hibiscus sabdariffa L.). Journal of Pharmaceutical Research International. 2021; 33(46B): 186-192.

Sundang, Murni, Sharifah Norfarahani Syed Nasir, Coswald Stephen Sipaut, and Hasanah Othman. 2012. “Antioxidant Activity, Phenolic, Flavonoid and Tannin Content of Piper Betle and Leucosyke Capitella Murni.” Malaysian Journal of Fundamental & Applied Sciences 8 (1): 1–6.

Widowati, Wahyu, L G Don, L Dendrophtoe, and T D Cancer Cell. 2011. “The Comparison of Antioxidative and Proliferation Inhibitor Properties of Piper Betle L ., Catharanthus Roseus [ L ... The Comparison of Antioxidative and Proliferation Inhibitor Properties of Piper Betle L ., Catharanthus.” International Research Journals Full 1: 022–028.

Wismarini, Th Dwiati, Dwi Budi, and Dewi Handayani Untari Ningsih. 2012. “Elektronik Ensiklopedi Tanaman Herba Sebagai Bank Data Digital Tanaman Obat.” Jurnal Teknologi Informasi Dinamik 17 (2): 90–97.