REVIEW ARTIKEL: SISTEM PENGHANTARAN OBAT SNEEDS (Self-Nanoemulsifying Drug Delivery System) DALAM FORMULASI OBAT HERBAL
Abstrak
SNEDDS adalah sistem penghantaran obat yang mempunyai tujuan untuk memberikan peningkatan kelarutan msupun bioavailabilitas obat yang sukar larut dalam air. Meningkatnya bioavailabilitas mampu membenahi profil kinetika obat di dalam tubuh. Review artikel ini memiliki tujuan agar dapat membahas perihal keunggulan, formulasi SNEDDS yang digunakan untuk pembuatan obat dengan ekstrak bahan alam. Metode penelitian yang diterapkan dalam artikel ini yaitu literature review dengan melakukan pengumpulan artikel dalam wujud jurnal tentang formulasi SNEDDS obat herbal. SNEDDS menggabungkan beragam jenis minyak, surfaktan serta kosurfaktan. Pemlilihan komposisi formulasi SNEDDS harus dibuat dengan kecermatan yang tinggi. Penelitian dan pengembangan SNEDDS sudah banyak memperlihatkan potensi SNEDDS dalam memberikan peningkatan terhadap kelarutan serta bioavailabilitas obat yang sukar larut dalam air. Walaupun terdapat banyak tantangan yang harus dihadapi pada SNEDDS, namun SNEDDS berpotensi besar pada peningkatan efisiensi terapi obat.
Referensi
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