POTENSI AKTIVITAS ANTIINFLAMASI DAN ANTIKANKER DARI EKSTRAK DAN FRAKSI DAUN ALPUKAT DAN DAUN PEPAYA: NARRATIVE REVIEW
Abstrak
Daun alpukat dan daun pepaya secara empiris telah banyak digunakan masyarakat Indonesia sebagai obat tradisional dengan berbagai macam khasiat. Penemuan dan pengembangan obat baru yang mengarah pada pemanfaatan tanaman obat berkhasiat memicu dibutuhkannya informasi yang akurat dan terpercaya khususnya terkait daun alpukat dan daun pepaya dalam pengobatan penyakit kanker dan inflamasi. Penulisan artikel ini bertujuan untuk mengetahui potensi dari daun alpukat dan daun pepaya baik dalam bentuk ekstrak maupun fraksi terhadap aktivitas antiinflamasi dan antikanker yang dihimpun dalam artikel narrative review. Pencarian artikel sebagai bahan referensi penulisan dilakukan dengan menggabungkan kata kunci dan boolean operator (AND, OR) yang diketikkan pada situs database artikel seperti Google Scholar, PubMed, dan Researchgate. Terdapat kriteria inklusi dalam pencarian artikel yaitu artikel yang relevan pada jurnal yang telah terpublikasi pada tahun 2015 hingga 2024, artikel tersedia dalam full-text berbahasa Indonesia atau Inggris, serta diperoleh dari desain penelitian experimental study. Berdasarkan hasil seleksi artikel jurnal, diperoleh sebanyak 23 artikel jurnal yang telah memenuhi kriteria inklusi untuk dilakukan proses review. Hasil pengkajian 23 artikel menunjukkan bahwa daun alpukat dan daun pepaya telah terbukti secara ilmiah memiliki aktivitas farmakologi sebagai antiinflamasi dan antikanker baik dalam bentuk ekstrak maupun fraksi. Adapun kandungan senyawa metabolit sekunder yang diduga bertanggung jawab terhadap dihasilkannya aktivitas antiinflamasi dan antikanker pada tanaman daun alpukat dan daun pepaya adalah senyawa golongan flavonoid.
Referensi
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