PENGGUNAAN METFORMIN PADA PASIEN POLYCYSTIC OVARY SYNDROME (PCOS)
Abstract
Infertility in women of reproductive age with Polycystic Ovary Syndrome (PCOS) in Indonesia is increasing. Insulin resistance occurs in some PCOS patients, so the use of insulin sensitivity-enhancing drugs such as metformin is recommended. This study was conducted to determine the use of metformin in PCOS patients at independent doctor's practices in Bandung City. The study was conducted as an observational descriptive study with data collected retrospectively using purposive sampling. Data were taken from patient medical records and interviews with the doctor in charge. The sample in this study consisted of patients who met the inclusion and exclusion criteria. The data obtained were then summarized and displayed in table form. The results showed that the majority of PCOS patients were 26-30 years old with marriages that had lasted for 3 years. Ovulation and pregnancy in PCOS patients who used oral metformin treatment occurred in 15% of cases. The metformin used had a dose of 500-850 mg, which was given twice a day for 4-9 months.
References
Christine, Halimah, E., & Yohanes, D. C. (2023). Review Artikel: Pengaruh Metformin sebagai Off-Label Untuk Terapi pada Wanita dengan Polycystic Ovary Syndrome (PCOS). Farmaka, 21(1), 64–77. https://doi.org/https://doi.org/10.24198/farmaka.v21i1.44306.g19753
Dewi, N. L. P. R. (2020). Pendekatan Terapi Polycystic Ovary Syndrome (PCOS). Cermin Dunia Kedokteran (CKD) - 290, 47(9), 703–705. https://doi.org/https://doi.org/10.55175/cdk.v47i9.571
Hanani, D. S., Ardiyanti, A., & Ika, N. V. (2023). Hubungan Dukungan Sosial terhadap Kecemasan Pasien Polycycstic Ovary Syndrome (PCOS). Detector: Jurnal Inovasi Riset Ilmu Kesehatan, 1(3), 197–211. https://doi.org/10.55606/detector.v1i3.2238
Hendarto, H., Wiweko, B., Santoso, B., & Harzif, A. K. (2019). Konsensus Penanganan Infertilitas (2 ed.). Himpunan Endokrin Reproduksi dan Fertilitas Indonesia (HIFERI) - Perkumpulan Obstetri dan Ginekologi Indonesia (POGI).
Menteri Kesehatan Republik Indonesia. (2020). Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/603/2020 tentang Pedoman Nasional Pelayanan Kedokteran Tata Laksana Diabetes Melitus Tipe 2 Dewasa. Kementrian Kesehatan.
Naderpoor, N., Shorakae, S., De Courten, B., Misso, M. L., Moran, L. J., & Teede, H. J. (2015). Metformin and lifestyle modification in polycysticovary syndrome: Systematic review and meta-analysis. Human Reproduction Update, 21(5), 560–574. https://doi.org/10.1093/humupd/dmv025
Penzias, A., Bendikson, K., Butts, S., Coutifaris, C., Falcone, T., Fossum, G., Gitlin, S., Gracia, C., Hansen, K., La Barbera, A., Mersereau, J., Odem, R., Paulson, R., Pfeifer, S., Pisarska, M., Rebar, R., Reindollar, R., Rosen, M., Sandlow, J., & Vernon, M. (2017). Role of Metformin for Ovulation Induction in Infertile Patients with Polycystic Ovary Syndrome (PCOS): A Guideline. Fertility and Sterility, 108(3), 426–441. https://doi.org/10.1016/j.fertnstert.2017.06.026
Susanto, C. A., & Wiweko, B. (2016). Efek Metformin dan DLBS3233 terhadap Kadar Anti-Mullerian Hormon pada Wanita Sindrom Ovarium Polikistik: Uji Klinis Acak Tersamar Ganda [Tesis]. Universitas Indonesia.
Togi, H. B. (2017). Pola Penggunaan Metformin secara Off-Label pada Pasien Penderita Polycystic Ovary Syndrome (PCOS) di Salah Satu Apotek di Bandung [Skripsi]. Sekolah Tinggi Farmasi Bandung.
Vitek, W., Alur, S., & Hoeger, K. M. (2015). Off-Label Drug Use in The Treatment of Polycystic Ovary Syndrome. Dalam Fertility and Sterility (Vol. 103, Nomor 3, hlm. 605–611). Elsevier Inc. https://doi.org/10.1016/j.fertnstert.2015.01.019
Zetira, Z., Rodiani, & Fakhruddin, H. (2019). Pengaruh Metformin Terhadap Wanita Infertilitas dengan Sindrom