KOKRISTALISASI KETOPROFEN-ASAM TARTRAT-NaCl UNTUK PENINGKATAN SIFAT KELARUTAN

Muhammad Taqiyyuddin Fahmi; Eka Deddy Irawan; Budipratiwi Wisudyaningsih; Kuni Zu’aimah Barikah; Yudi Wicaksono

doi:10.36805/jbf.v4i2.1021

Muhammad Taqiyyuddin Fahmi 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia
Eka Deddy Irawan Kelompok Riset Penghantaran Obat Fakultas Farmasi Universitas Jember, Jember, Indonesia
Budipratiwi Wisudyaningsih 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia
Kuni Zu’aimah Barikah 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia
Yudi Wicaksono 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia

DOI: https://doi.org/10.36805/jbf.v4i2.1021

Kata Kunci: Ketoprofen, kokristalisasi, asam tartrat, NaCl, kelarutan

Abstrak

Ketoprofen merupakan senyawa obat dengan efek analgesik, antiinflamasi, dan antipiretik yang mempunyai kelarutan sangat rendah. Tujuan penelitian adalah peningkatan kelarutan ketoprofen dengan metode kokristalisasi. Kokristalisasi dilakukan dengan metode penguapan pelarut menggunakan koformer asam tartrat dan penambahan garam anorganik NaCl. Karakterisasi padatan kokristal dilakukan dengan PXRD, DSC, FTIR dan SEM. Kokristal dievaluasi kelarutan dan disolusinya dalam media air suling. Hasil karakterisasi menunjukkan bahwa padatan kokristal ketoprofen-asam tartrat-NaCl merupakan padatan kristalin yang mempunyai sifat padatan berbeda dibandingkan padatan bahan awal ketoprofen dan asam tartrat. Kokristal ketoprofen-asam tartrat-NaCl menunjukan kelarutan dan disolusi ketoprofen yang lebih tinggi secara signifikan (p<0,05) dibandingkan kelarutan dan disolusi ketoprofen awal

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