POTENSI TANAMAN HERBAL SEBAGAI STIMULAN SISTEM SARAF PUSAT: LITERATURE REVIEW ARTICLE
Abstract
Energy drinks are consumed as supplement to increase energy and reduce fatigue. Herbal medicine has proven reduce fatigue in the body. This literature review aims to determine the types of herbal medicine that have properties as stimulants. This study used descriptive methode using the Population-Intervention-Controling-Outcome Framework. A literature search on studies published in the period 2012-2022 on the Google Scholar and Pub-Med using the keywords: stimulant, central nervous system, tonic, and herbal. Articles that cannot be accessed in full and herbal medicine that are not original from Indonesia will be excluded as samples. There were 1937 articles obtained based on the keywords used, a total of 91 articles met the inclusion criteria and 60 articles were excluded. Based on 30 articles reviewed, there are 31 types of herbal medicines that can increase stimulants with the most family is zingiberaceae and piperaceae. The combination of plant has a better stimulant effect than using the single plants. In vivo test method with the swimming endurance test as the most widely used. Flavonoid, alkaloid and terpenoid compounds are most likely to be effective as stimulants which have the same mechanism with caffeine through inhibition of Adenosine A1 receptors. This study shows there are 31 herbal medicine that have the potential to increase stimulants. Secondary metabolites which stimulant effects are flavonoids, alkaloids and terpenoids
References
Agustien, G. S., & Susanti, S. (2020). Uji Aktivitas Tonikum Infusa Buah Kapolaga (Amomum cardamomum) Pada Mencit (Mus musculus). Jurnal Farmagazine, 7(1), 32. https://doi.org/10.47653/farm.v7i1.152
Aladeokin, A. C., & Umukoro, S. (2011). Psychopharmacological properties of an aqueous extract of Tetracarpidium conophorum Hutch . & Dalziel in mice. 411–416. https://doi.org/10.1007/s11418-011-0506-1
Alifta. (2022). Hubungan Antara Konsumsi Minuman Berenergi Dengan Kejadian Gagal Ginjal Kronis Pada Pasien Hemodialisa di RSUD Dr Moewardi Surakarta. Naskah Publikasi.
Anas, Y., Puspitasari, N., & Nuria, M. C. (2013). Aktivitas Stimulansia Ekstrak Etanol Bunga Dan Daun Cengkeh (Syzygium aromaticum (L) Merr. & Perry.) Pada Mencit Jantan Galur Swiss Beserta Identifikasi Golongan Senyawa Aktifnya. 13–22.
Aprilia, F., & Siregar, T. (2011). Uji Aktivitas Stimulan Sistem Syaraf Pusat Ekstrak Biji Pinang ( Areca catechu L.) Terhadap Mencit Putih ( Mus Musculus L.) Dan Penentuan Ed 50 Yang Diberikan Secara Oral 1. Prosiding Seminar Nasional Matematika Dan Teknologi, 4, 51–58.
Artini, K. S., & Veranita, W. (2021). Tamanam Herbal untuk Meningkatkan Sistem Imun Tubuh: Literature Review. Jurnal Farmasetis, 10(1), 15–20. https://doi.org/10.32583/farmasetis.v10i1.1383
Basit Erlangga, A., Mulyati Effendi, E., & Wiendarlina, I. Y. (2015). Uji Efektivitas Kombinasi Esktrak Cabe Jawa (Piper retroftactum Vahl.) dan Biji Mahoni (Swietenia mahagoni Jacq.) Sebagai Penambah Stamina Pada Tikus Jantan (Sprague Dawley). Acta Veterinaria Indonesia , 3(2), 64–69.
Boondam, Y., Songvut, P., Tantisira, M. H., Tapechum, S., Tilokskulchai, K., & Pakaprot, N. (2019). Inverted U-shaped response of a standardized extract of Centella asiatica (ECa 233) on memory enhancement. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-44867-z
Chassot, J. M., Longhini, R., Gazarini, L., Carlos, J., Mello, P., Maria, R., & Oliveira, W. De. (2011). Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice. Journal of Ethnopharmacology, 137(3), 1143–1148. https://doi.org/10.1016/j.jep.2011.07.032
Davis, J. M., Zhao, Z., Stock, H. S., Mehl, K. A., Buggy, J., Hand, G. A., Mark, J., Zhao, Z., Stock, H. S., Mehl, A., Buggy, J., & Cen-, G. A. H. (2003). Central nervous system effects of caffeine and adenosine on fatigue. 29208, 399–404.
Dayanthi, N. P. K. (2016). Uji Klinis Aktivitas Tonikum Dari Ekstrak Rimpang Kencur (Kaempferia Galanga L) Dengan Metoda Harvard Step Test. Universitas Andalas.
Debnath, B., Somraj, W., Das, M., Goswami, S., Kumar, M., Maiti, D., & Manna, K. (2018). Role of plant alkaloids on human health : A review of biological activities. Materials Today Chemistry, 9, 56–72. https://doi.org/10.1016/j.mtchem.2018.05.001
Fathnur Sani K, Yuliawati, Herlina, R. Y. (2020). Uji efek tonikum ekstrak daun sawo manila (Manilkara zapota) pada mencit putih jantan (Mus musculus) dengan metode ketahanan renang Fathnur. Riset Informasi Kesehatan, 9(1), 37–42. https://doi.org/10.30644/rik.v8i2.267
Febrinasari, N., Wijayanti, R., & Apriadi, A. (2016). Uji Stimulansia Ekstrak Kulit Umbi Bawang Putih ( Allium sativum L . ) Pada Mencit Galur Swiss / Stimulantia Test Of Garlic BULB ( Allium sativum L .) Extract On Swiss Webster Mice. Jurnal Farmasi Dan Sains Praktis, I(2), 42–49.
Fröhlich, E., & Salar-Behzadi, S. (2014). Toxicological assessment of inhaled nanoparticles: Role of in vivo, ex vivo, in vitro, and in Silico Studies. International Journal of Molecular Sciences, 15(3), 4795–4822. https://doi.org/10.3390/ijms15034795
Gina Septiani Agustien, S. (2020). Uji Aktivitas Tonikum Infusa Buah Kapolaga (Amomum cardamomum) Pada Mencit (Mus musculus) TEST. VII(1), 32–36.
Houghton, P. J., & Raman, A. (1998). Analysis of crude extracts, fractions and isolated compounds. Laboratory Handbook for the Fractionation of Natural Extracts, 113–138. https://doi.org/10.1007/978-1-4615-5809-5_8
Indriana, T. (2010). Pengaruh Kelelahan Otot Terhadap Ketelitian Kerja. Stomatognatic, 7(49–52).
Januarti, I. B., Latifah, F., & Wajha, A. I. (2020). Efek Stimulansia Ekstrak Etanolik Umbi Bawang Putih Tunggal ( Allium Sativum Var . Solo Garlic ) Terhadap Mencit Galur Swiss. Jurnal Farmasi Indonesia, 17(2), 1–9.
Methley, A. M., Campbell, S., Chew-Graham, C., McNally, R., & Cheraghi-Sohi, S. (2014). PICO, PICOS and SPIDER: A comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. In BMC Health Services Research (Vol. 14, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s12913-014-0579-0
Metrikana Novembrina, Poppy Diah Palupi, F. B. (2019). Uji Efektivitas Ekstrak Etanol 70% Ekstrak Kawista (Limonia acidissima ) Sebagai Tonikum Pada Mencit Jantan Galur Swiss. Jurnal Farmasi & Sains Indonesia, 2(1), 48–53.
Moerfiah, Yulianita, D. S. (2019). Effectiveness Stimulance Of Combination Of Beetroot And Apple Juice On Physical Resistance And Hb Levels In White Rat Sprague Dawley. Ekologia: Jurnal Ilmiah Ilmu Dasar Dan Lingkungan Hidup, 19(April), 20–26.
Moerfiah, Yulianita, & Setiawan, D. (2019). Efektivitas Stimulansia Kombinasi Sari Umbi Bit Dan Buah Apel Terhadap Ketahanan Fisik Dan Kadar Hb Tikus Putih Sprague Dawley. Ekologia: Jurnal Ilmiah Ilmu Dasar Dan Lingkungan Hidup, 19(1), 20–26. https://doi.org/10.33751/ekol.v19i1.1658
PERNEFRI. (2018). 11th report Of Indonesian renal registry 2018. Indonesian Renal Registry (IRR), 14–15.
Prastiwi, R., & Farmasi Bhumi Husada Jakarta, A. (2015). Uji Efek Tonik ekstrak Etanol Herba Pegagan (Centella asiatica (L). Urb) pada Mencit Jantan Balb/C. 5(1).
Puspitasari, L. (2017). Ekstrak etanol daun pandan wangi (pandanus amaryllifolius r.) 10% menurunkan immobility time dan kadar kortisol tikus jantan galur wistar yang depresi 8(1), 24–30. https://doi.org/10.1556/ism.v8i1.107
Rahimatul Uthia, Helmi Arifin, F. E. (2017). Pengaruh Hasil Fraksinasi Ekstrak Daun Kemangi (Ocimum sanctum L.) Terhadap Aktivitas Susunan Saraf Pusat Pada Mencit Putih Jantan. Jurnal Farmasi Higea, 9(1), 85–95.
Rejeki, S., & Priyandari, A. (2017). Uji Efek Tonikum Ekstrak Etanol Rimpang Lempuyang Gajah (Zingiber zerumbet SM.) Terhadap Mencit Jantan Galur Swiss. 4(2), 232–236.
Retnani, Y., & Parmadi, A. (2014). Perbandingan Efek Tonikum Ekstrak Etanol Jahe Merah (Zingiber Officinale Var.Rubrum) Dan Jahe Putih (Zingiber Officinale Var.Album) Pada Mencit Jantan (Mus Musculus L.) Ras Swiss. IJMS - Indonsian Journal on Medical Science, 1(2), 76–80.
Rini Prastiwi, R.Tjahyadi, C. (2015). Uji Efek Tonik Ekstrak Etanol Herba Pegagan (Centella asiatica (L). Urb) Pada Mencit Jantan Balb/C Rini. 5(1), 19–23.
Riskesdas. (2019). Laporan Nasional RISKESDAS 2018. In Kementerian Kesehatan RI (Vol. 10, p. 126). Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan (LPB).
Saha, S., & Banerjee, S. (2014). Central nervous system stimulant actions of Alpinia galanga ( L .) rhizome : A preliminary study. Indian Journal of Experimental Biology, 51(January 2013), pp 828-832.
Setyawati, E. R., & Endrawati, S. (2019). Uji Efek Tonikum Ekstrak Etanol Rimpang Temu Kunci (Boesenbergia pandurata ( Roxb ) Schlecht ) Terhadap Mencit Jantan Galur Swiss The Tonict. 6(2), 52–56.
Sumarny, R. O. S., Rahayu, L., Made, N. I., & Sandhiutami, D. W. I. (2013). Efek Stimulansia Infus Lada Hitam ( Piperis nigri fructus ) Pada Mencit ( Stimulant effect of infusion of black pepper ( Piperis nigri fructus ) in mice ). Jurnal Ilmu Kefarmasian Indonesia, 11(2), 142–146.
Sumarsono, D. D., Gunawan, Y. E., & Panda, A. (2019). Pengaruh Pemberian Air Rebusan Akar Ilalang ( Imperata cylindrica ) Terhadap Stamina Mencit Jantan ( Mus musculus ). Jurnal Jejaring Matematika Dan Sains, 1(2), 92–96.
Suri, N., Mulyaningsih, Devvy Wahyu, & Melani, D. (2022). Evaluasi Permasalahan Terkait Obat Pada Pasien Gagal Ginjal Kronik Dengan Komplikasi Hipertensi Dan Diabetes Melitus Tipe Ii Di Rumah Sakit Umum Daerah Provinsi Lampung. Jurnal Ilmu Kedokteran Dan Kesehatan, 9(3).
Suri, N., Widodo, S., & Yulianti, M. I. (2021). Uji Efek Stimulan Fraksi N-Heksan Daun Pegagan (Centella Asiatica (L.)Urban). Jurnal Farmasi Lampung, 10(2). https://doi.org/10.37090/jfl.v10i2.703
Vivi, H. F. L. and. (2013). Uji Anti Lelah (Anti Fatigue) Kombinasi Nira Aren Dan Air Tebu Dengan Metode Ketahanan Berenang (Natatory Exhaustion) Pada Mencit Jantan. 10(02), 124–137.
Widianingrum, M., & Herdwiani, W. (2012). Uji Efek Tonikum Infusa Batang Pasak Bumi dan Campuran Batang Pasak Bumi , Rimpang Jahe Merah dan Buah Cabe Jawa terhadap Mencit Putih Jantan,. Jurnal Farmasi Indonesia, 9(1), 37–43.
Widianingrum, M., Suhartinah, & Herdwiani, W. (2012). Uji Efek Tonikum Infusa Batang Pasak Bumi dan Campuran Batang Pasak Bumi, Rimpang Jahe Merah dan Buah Cabe Jawa terhadap Mencit PutihJantan. Jurnal Farmasi Indonesia, 9(1), 37–43. http://farmasiindonesia.setiabudi.ac.id/
Yulianita, ., & Effendi, E. M. (2016). Uji Efektivitas Jangka Panjang Kombinasi Ekstrak Buah Cabe Jawa dan Biji Mahoni Sebagai Penambah Stamina pada Tikus Putih Jantan. Acta VETERINARIA Indonesiana, 3(2), 64–69. https://doi.org/10.29244/avi.3.2.64-69
Zaman, A., Khan, M. S. S., Akter, L., Syeed, S. H., Akter, J., Al Mamun, A., Alam, M. E., Habib, M. A., & Jalil, M. A. (2015). Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region. BMC Complementary and Alternative Medicine, 15(1). https://doi.org/10.1186/s12906-015-0635-2
Zhang, X., Geng, P., Zhang, T., Lu, Q., Gao, P., & Mei, J. (2020). Aceso: PICO-Guided Evidence Summarization on Medical Literature. IEEE Journal of Biomedical and Health Informatics, 24(9), 2663–2670. https://doi.org/10.1109/JBHI.2020.2984704
