STUDI FITOKIMIA DAN AKTIVITAS FARMAKOLOGI DARI KULIT BATANG MESOYI (Massoia aromatica Becc.)
Keywords:
Mesoyi bark, Massoia aromatica Becc., phytochemicals, pharmacology, immunomodulators, in vivo, in vitro
Abstract
For a long time, nature with all its wealth has been used by humans as a necessity of life including medicine. Today, traditional medicine with the use of plants is much in demand by people all over the world. One of the benefits-rich plants commonly used is the skin of the mesoyi stem (Messoia aromatica Becc.) which phytochemically contains flavonoid compounds, phenolics, alkaloids, steroids, triterpenoids, saponins, tannins, calcons, and coumarins. Based on pharmacological studies this plant can act as antimicrobial, phagocytic, cytotoxic, anti-inflammatory, immunomodulatory, antioxidant, analgetic, as well as other effects by inhalation. However, if further research is done, there may be more pharmacological activity resulting from this plant. Therefore, research on this plant still needs to be developed so that it can be used as a reference for traditional medicine.
References
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Harborne, JB. 1998. Phytochemicalmethods: A guide to modern techniquesof plant analysis. Champman and Hall: London.
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Hawariah, ALP., Munawar, M., dan Laily, D. Antifertility Effect of Goniothalamin: A Styrylpyrone Isolated from Goniothalamus Tapis Miqo. Asia Pacific Journal Pharmacology. 1994;9:273-277.
Hawariah, ALP., dan Stanslas, J. In Vitro Response of Human Breast Cancer Cell Lines To the Growth-Inhibitory Effects of Styrylpyrone Serivative (SPD) and Assessment of Its Antiestrogenicity. Anticancer Res. 1998;18:4383-4386.
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Hertiani, T., Agustinus, Y., Sylvia, UTP., dan Harlyanti, MM. Effect of Massoia (Massoia aromatica Becc.) Bark on the Phagocytic Activity of Wistar Rat Macrophages. Scientia Pharmaceutical. 2018;86(19):1-7.
Hutapea, FJ. Masoi: Hasil Hutan Bukan Kayu Papua yang Tidak Terkelola dengan Baik. Buletin Tritonis. 2017;1:35-36.
Hutapea, FJ., dan Wijaya, DJW. Hasil Hutan Bukan Kayu Unggulan Papua Barat. Buletin Tritonis. 2017; 2: 37-39.
Hutapea, FJ., Kuswandi, R., dan Asmoro, JP. Potency and Distribution of Massoi (Cryptocarya massoy) in Teluk Bintuni and Kaimana Regencies. Journal of Forestry Research. 2019;4(1):57-70.
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Joko, S., Jarot, Y., dan Estika, S. 2018. Perbandingan Effektivitas Daya Analgetika Antara Celecoxib Dan Antalgin (Metampiron) Pada Mencit Jantan (Mus Musculus) Dengan Metode Witkin. Jurnal Permata Indonesian. 2018;9(1):38-46.
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Alkandahri, MY., Berbudi, A., and Subarnas, A. Active Compounds and Antimalaria Properties of some Medicinal Plants in Indonesia – A Review. Systematic Reviews in Pharmacy. 2018; 9(1): 64-69.
Alkandahri, MY., Subarnas, A., dan Berbudi A. Aktivitas Immunomodulator Tanaman Sambiloto (Andrographis paniculata Nees) – Review. Farmaka. 2018; 16(3): 16-21.
Alkandahri, MY., Siahaan PN., Salim, E., and Fatimah, C. Anti-Inflammatory Activity of Cep-cepan Leaves (Castanopsis costata (Blume) A.DC). International Journal of Current Medical Sciences. 2018; 8(4A): 424-429.
Alkandahri, MY., Berbudi, A., Utami, NV., and Subarnas, A. Antimalarial Activity of Extract and Fractions of Castanopsis costata (Blume) A.DC. Avicenna Journal of Phytomedicine. 2019; 9(5): 474-481.
Alkandahri, MY., Maulana, YE., Subarnas, A., Kwarteng, A., and Berbudi, A. Antimalarial Activity of Extract and Fractions of Cayratia trifolia (L.) Domin. International Journal of Pharmaceutical Research. 2020; 12(1): 1435-1441.
Alkandahri, MY., Kusumawati, AH., and Fikayuniar, L. Antibacterial Activity of Zingiber officinale Rhizome. International Journal of Psychosocial Rehabilitation. 2020; 24(7): 3702- 3706.
Alkandahri, MY., Patala, R., Pratiwi, MI., Agustina, LS., Farhamzah, Kusumawati, AH., Hidayah, H., Amal, S., and Frianto, D. Pharmacological Studies of Durio Zibethinus: A Medicinal Plant Review. Annals of the Romanian Society for Cell Biology. 2021; 25(4): 640-646.
Alkandahri, MY., Shafirany, MZ., Rusdin, A., Agustina, LS., Pangaribuan, F., Fitrianti, F., Farhamzah, Kusumawati, AH., Sugiharta, S., Arfania, M., and Mardiana, LA. Amomum compactum: A Review of Pharmacological Studies. Plant Cell Biotechnology and Molecular Biology. 2021; 22(33&34): 61-69.
Alkandahri, MY., Sujana, D., Hasyim, DM., Shafirany, MZ., Sulastri, L., Arfania, M., Frianto, D., Farhamzah., Kusumawati, AH., and Yuniarsih, N. Antidiabetic Activity of Extract and Fractions of Castanopsis costata Leaves on Alloxan-induced Diabetic Mice. Pharmacognosy Journal. 2021; 13(6)Suppl: 1589- 1593.
Atmadja, WR., Ma’mun., dan Songdang, S. Efektivitas Minyak Masoyi (Massoia aromatica) terhadap Helopeltis antonii Sign Pada Jambu Mete dan Chrysocoris javanus pada Jarak Pagar. Bul Littro. 2009;20(2):141-147.
Barnes, J., Anderson, LA., Phillipson, JD. 2007. Herbal Medicine, 3rd Edition. Pharmaceutical Press: London. 1-23.
Batubara, I., Prayogo, Y., Suparto, I., et al. Inhalation Effect of Massoilactone from Massoia Essential Oil on Lipid Profile, Liver Tissues, and Body Weight of Sprague Dawley Rat. Journal of Applied Pharmaceutical Science. 2019;9(8):111-116.
Belteghi, C. Mecanisme Moleculare De Acţiune Ale Imunomodulatorilor Molecular Action Mechanisms Of The Immunomodulators. Medicamentul Veterinar. 2008;2(1).
Bina, LS., Wandesta, R., dan Partomuan, S. Toksisitas, Aktivitas Antioksidan & Antibakteri Ekstrak Air Kulit kayu Massoi (Cryptocarpa massoy (Lauraceae)). Jurnal Ilmiah Farmasi. 2015;4(1):18-26.
Brodowska, KM. Natural Flavonoids: Classification, Potential Role, and Application of Flavonoid Analogues. European Journal of Biological Research. 2017;7(2):108-123.
Carmona, F., dan Pereira, AMS. Herbal Medicines: Old and New Concepts, Truths and Misunderstandings. Brazilian Journal of Pharmacognosi. 2013;23(2):379-385.
Check, W. Kekebalan bawaan bergantung pada reseptor seperti Toll, ASM News. 2004;70(7):317-322.
Cho, SJ., Valerie, HL., Wu-Sing, SH., dan Sing, KY. Novel Cytotoxic Polyprenilaterd Xanthones from Garcinia gaundichaudii (Guttiferae). Tetrahedron. 1998;54:10915-10924.
Drewers, SE., Horn, MH., dan Mavis, S. Cryptocarya Liebertiana and Ocotea Bullata-Their.
Edwards, JP., Zhang, X., Frauwirth, KA., dan Mosser, DM. Biochemical and Functional Characterization of Three Activated Macrophage Populations. Journal of Leukocyte Biology. 2006;80(6):1298-1307.
Farhamzah, Kusumawati, AH., Alkandahri, MY., Hidayah, H., Sujana, D., Gunarti, NS., Yuniarsih, N., Apriana, SD., and Agustina, LS. Sun Protection Factor Activity of Black Glutinous Rice Emulgel Extract (Oryza sativa var glutinosa. Indian Journal of Pharmaceutical Education and Research. 2022; 56(1): 302- 310.
Gan, S. 1980. Farmakologi Terapi, Edisi Ketiga. Bagian Farmakologi Kedokteran UI: Jakarta.
Harborne, JB. 1998. Phytochemicalmethods: A guide to modern techniquesof plant analysis. Champman and Hall: London.
Harikrishnan, R., Balasundaran, C., Heo, MS. Review: Impact of Plant Products on Innate and Adaptive Immune System of Cultured Finfish and Shellfish. Aquaculture. 2011;317:1-15.
Hassan, F., Soliman, GM., Okasha, EF., dan Shalaby, AM. Histological, Immunohistochemical, and Biochemical Study of Experimentally Induced Fatty Liver in Adult Male Albino Rat and the Possible Protective Role of Pomegranate. Journal Microscructure Ultrastructure. 2018;6:44-55.
Hawariah, ALP., Munawar, M., dan Laily, D. Antifertility Effect of Goniothalamin: A Styrylpyrone Isolated from Goniothalamus Tapis Miqo. Asia Pacific Journal Pharmacology. 1994;9:273-277.
Hawariah, ALP., dan Stanslas, J. In Vitro Response of Human Breast Cancer Cell Lines To the Growth-Inhibitory Effects of Styrylpyrone Serivative (SPD) and Assessment of Its Antiestrogenicity. Anticancer Res. 1998;18:4383-4386.
Hawariah, ALP., Stanslas, J., dan Laily, D. Non-steroid Receptor Mediated Antiproliferative Activity of Styrylpyrone Derivative in Human Breast Cancer Cell Lines. Anticancer Res. 1998;18:1739-1744.
Hertiani, T., Agustinus, Y., Sylvia, UTP., dan Harlyanti, MM. Effect of Massoia (Massoia aromatica Becc.) Bark on the Phagocytic Activity of Wistar Rat Macrophages. Scientia Pharmaceutical. 2018;86(19):1-7.
Hutapea, FJ. Masoi: Hasil Hutan Bukan Kayu Papua yang Tidak Terkelola dengan Baik. Buletin Tritonis. 2017;1:35-36.
Hutapea, FJ., dan Wijaya, DJW. Hasil Hutan Bukan Kayu Unggulan Papua Barat. Buletin Tritonis. 2017; 2: 37-39.
Hutapea, FJ., Kuswandi, R., dan Asmoro, JP. Potency and Distribution of Massoi (Cryptocarya massoy) in Teluk Bintuni and Kaimana Regencies. Journal of Forestry Research. 2019;4(1):57-70.
Hutchinson, J. 1969. Evolution and Phylogeny of Flowering Plants. Academic Press: London. 28
Jian, J., dan Wu, Z. Influences of Traditional Chinese Medicine on Non-Spesific Immunity of Jian Carp (Cyprinus carpoi var. Jian). Fish Shellfish Immunol. 2004; 16: 185-191.
Joko, S., Jarot, Y., dan Estika, S. 2018. Perbandingan Effektivitas Daya Analgetika Antara Celecoxib Dan Antalgin (Metampiron) Pada Mencit Jantan (Mus Musculus) Dengan Metode Witkin. Jurnal Permata Indonesian. 2018;9(1):38-46.
Khaira, K. 2010. Menangkal Radikal Bebas Dengan Antioksidan. Publish Jurnal Sainstek. 2010;2(2):183-187.
Karunamoothi, K., Jegajeevanram, K., Vijayalakshmi, J., dan Mengistie, E. Traditional Medicinal Plants: A Source of Phytotherapeutic Modality in Resource-Contrained Health Care Settings. Journal of Evidence-Based Complementary & Alternative Medicine. 2013;18(1):67-74.
Koolman, J., dan Rohm, K. H., 2001. Biokimia: Atlas Berwarna dan Teks, (Alih Bahasa Sadikin, M). Fakultas Kedokteran Universitas Indonesia: Jakarta.
Kunarto, B. 2006. Evaluasi Sifat Antioksidatif Mikrokapsul Minyak Atsiri Kulit Kayu Manis (Cinnamomum burmanii) yang Diaplikasikan pada Cookies. Jurnal Pertanian dan Kimia Makanan. 2006; 14(2): 85-94.
Kunle, OF., Egharevba, HO., dan Ahmadu, PO. Standarization of Herbal Medicines-A Review. International Journal of Biodiversity and Conservation. 2012;4(3):101-112.
Kuroh, B., dan Homot, PL. Cryptocarya massoy. The IUCN Red List of Threatened Specie.2019;e.T125918206A125918219:1-7.
Kusumawati, AH., Farhamzah, F., Alkandahri, MY., Sadino, A., Agustina, LS., and Apriana, SD. Antioxidant Activity and Sun Protection Factor of Black Glutinous Rice (Oryza sativa var. glutinosa). Tropical Journal of Natural Product Research. 2021; 5(11): 1958-1961.
Lalthanpuii, PB., dan Lalchhandama, K. Phytochemical Analysis and In Vitro Anthelmintic Activity of Imperata Cylndrica Underground Parts. BMC Complementary Medicine and Therapies. 2020;20(332):1-9.
Lee, KH, Huang, ES, Piantadosi, C, et al. Cytotoxicity of Sesquiterpene Lactones. Cancer Research. 1971;31(11):1649-54.
Munaeni, W., Pariakan,A., Yuhana, M., et al. In Vitro Phytochemical and Inhibitory Potential Tests of Buton Forest Onion Extract (Eleutherine palmifolia) on Vobrio harveyi. Michrobiology Indonesia. 2011;11(3):75-80.
Murningsih, T., Influence of Water and Ethanol Extracts of Kaempferial spp. to Phagocytosis Activity and Capacity Macrophage Cells Induce by Staphylococcus Epidermidis. Berita Biologi. 2010;10(2):235-240.
Nurfitriah, SF., Jayanti, K., Putri, BA., Trisnawati, T, Putri, R., Oktavia, SS, et al. Jurnal Buana Farma: Jurnal Ilmiah Farmasi. 2021; 1(3): 14-20.
Permanasari, P., Hertiani, T., dan Yuswanto, A. Efek imunomodulator dari ekstrak kulit kayu Massoia dan aktivitas sitotoksisitas terhadap sel fibroblast dan vero secara in vitro. International Conference on Pharmacy and Advanced Pharmaceutical Sciences. 2016;8(5):326-330.
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Published
2022-06-29
Section
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