EFEK PENGGUNAAN BETA BLOCKER TERHADAP KEJADIAN HIPOGLIKEMIA PADA LANSIA: NARRATIVE REVIEW
Abstract
Elderly patients are considered a vulnerable population, as advanced age may exacerbate existing conditions or predispose individuals to adverse effects such as hypoglycemia. While hypoglycemia most frequently occurs in patients with diabetes who are treated with insulin or oral hypoglycemic agents, it may also develop in non-diabetic individuals under certain circumstances. The use of beta-blockers has been identified as one potential contributing factor to hypoglycemic events. This article aims to review the adverse effects of beta-blocker therapy in relation to hypoglycemia among older adults. A narrative review was conducted through electronic databases including PubMed, Google Scholar, and ScienceDirect. The inclusion criteria were studies published within the last 10 years involving older patients who experienced hypoglycemia while receiving beta-blocker therapy. The search yielded 38 articles, of which only 4 met the inclusion criteria. In conclusion, the use of β-blockers appears to be associated with an increased risk of severe hypoglycemia; however, evidence specifically addressing the geriatric population remains limited.
References
American Diabetes Association. Standards of Care in Diabetes-2023. The Journal of Clinical and Applied Research and Education 2023; 46(1), 1–298.
Carnovale C., Gringeri M., Battini V., Mosini G., Invernizzi E., Mazhar F., Bergamaschi F., Fumagalli M., Zuccotti G., Clementi E., Radice S., Fabiano V., Beta-blocker-associated hypoglycaemia: New insights from areal-world pharmacovigilance study. British Journal of Clinical Pharmacology 2021; Volume 87, Issue 8.
Cole, J.N., Arens, A.M., Laes, J.R., Klein, L.R., Bangh, S.A., Olives, T.D., High dose insulin for beta-blocker and calcium channel-blocker poisoning. The American Journal of Emergency Medicine 2018; Volume 36, Issue 10, October 2018, Pages 1817-1824.
Dimakos, J., Cui, Y., Platt, R.W., Renoux, C., Filion, K.B., Douros, A. Concomitant Use of Sulfonylureas and β-Blockers and the Risk of Severe Hypoglycemia Among Patients With Type 2 Diabetes: A Population-Based Cohort Study. Diabetes Care 2023; 46(2):377–383.
Dungan K., Merrill J., Long C., Binkley P., Effect of beta blocker use and type on hypoglycemia risk among hospitalized insulin requiring patients, Cardiovascular Diabetology 2019; BMC 18:163, https://doi.org/10.1186/s12933 - 019 - 0967 – 1.
Ginting, R., Hutagalung, P. G. J., Hartono, H., & Manalu, P. Faktor-Faktor yang Mempengaruhi Pemanfaatan Program Pengelolaan Penyakit Kronis (Prolanis) pada lansia di Puskesmas Darussalam Medan. Jurnal Prima Medika Sains 2020; 2(2), 24–31. https://doi.org/10.34012/jpms.v2i2.972.
Kemenkes. Rencana Aksi Nasional Kesehatan Lanjut Usia Tahun 2020-2024. Kementrian Kesehatan Republik Indonseia 2021.
PERKENI. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2019. Perkumpulan Endokrinologi Indonesia 2019; 1–117.
PERKENI. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia 2024. Perkumpulan Endokrinologi Indonesia 2024; 88.
PERKI. Pedoman Tatalaksana Gagal Jantung (3rd ed.). Perhimpunan Dokter Spesialis Kardiovaskular Indonesia 2023.
Tandah., M.R., Hardani, M.F., Putri, D.A., Masyita, A.A., Safarudin, R., Adisaputra, A.D. Identification Of Potentially Inappropriate Medication (PIM) Based On Beers Criteria In Geriatric Inpatient At Anutapura Hospital Palu City, Central Sulawesi Province Indonesia: A Descriptive Cross-Sectional Design. Gomal Journal of Medical Sciences 2025; January - March 2025, Vol. 23, No. 1 (Special).
Tsujimoto, T., Sugiyama, T., Shapiro, M.F., Noda, M., Kajio, H., Risk of Cardiovascular Events in Patients with Diabetes Mellitus on β-Blockers. Hypertension AHA 2017; 70(1):103–110.