POTENSI TUMBUHAN JAMBLANG (Syzygium cumini (L.) Skeels) SEBAGAI HEPATOPROTEKTOR BERDASARKAN KANDUNGAN SENYAWA AKTIF : LITERATURE REVIEW ARTICLE

Himyatul Hidayah; Neni Sri Gunarti; Salsa Putri Oktaviani; Surya Amal

doi:10.36805/jbf.v3i1.774

Himyatul Hidayah Fakultas Farmasi, Universitas Buana Perjuangan, Karawang, Jawa Barat, Indonesia
Neni Sri Gunarti Fakultas Farmasi, Universitas Buana Perjuangan, Karawang, Jawa Barat, Indonesia
Salsa Putri Oktaviani Fakultas Farmasi, Universitas Buana Perjuangan, Karawang, Jawa Barat, Indonesia
Surya Amal Fakultas Farmasi, Universitas Buana Perjuangan, Karawang, Jawa Barat, Indonesia

DOI: https://doi.org/10.36805/jbf.v3i1.774

Keywords: Syzygium cumini, hepatoprotector, jamblang

Abstract

Damage to the liver can cause disruption of metabolism in the body, so a hepatoprotector is needed as a protector from liver damage which can be obtained from jamblang plants. The aim of this research is to know the content of active compounds contained in jamblang plants which work as hepatoprotectors. By reviewing some of the literature related to this, the results obtained were 10 articles used. In this study using Literature Review Article through electronic data sources, namely: Google Scholar, ScienceDirect and Pubmed which were published 10 years ago with the keywords: Syzygium cumini (L) and hepatoprotector. Based on the results of the research that has been done, the jamun plant contains the compounds β-sitosterol, friedelin, Betulinic acid, flavonoids, terpenes, alkaloids, phenolics, ellagic acid, glucoside, anthocyanins, kaempferol, quercetin, isoquercetin, myricetin, tannins, carbohydrates, albumin, and so on which can be used as antiviral, cardioprotective, anti-inflammatory, anticancer, antidiabetic, carminative, antihypertensive, anti-atherosclerotic, antifungal, antioxidant and hepatoprotector. It can be concluded that the active compounds that work as hepatoprotectors are the chemical compounds flavonoids and β-sitosterol which are located in the fruit seeds and leaves.

References

Alkandahri, MY., Pamungkas, BT., Oktoba, Z., Shafrany, MZ., Sulastri, L., Arfania, M., et al. (2023). Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety. Adv Pharmacol Pharm Sci. 2023(Article ID 1387665): 1-16.

Annisya, R. (2011). Pengaruh Pemberian Ekstrak Biji Buah Jamblang (Syzygium cumini) terhadap Penurunan Jumlah Sel Hati Nekrosis dan Apoptosis pada Tikus (Rattus norvegicus) Terinduksi Isoniazid. Skripsi. Fakultas Kedokteran. Universitas Sebelas Maret.

Hadary, A. E and Hassanien, M. F. R. (2016). Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)- induced hepatotoxicity in rats. Pharmaceutical Biology. Vol 54, No.8, 1364-1372.

Hidayah H, Amal S, Yuniarsih N, Farhamzah, Kusumawati AH, Gunarti NS, et al. (2023). Sun Protection Factor Activity of Jamblang Leaves Serum Extract (Syzygium cumini). Pharmacognosy Journal. 15(1): 134-140.

Ismeri. (2011). Aktivitas Ekstrak Etano; Air Daun Kari (Murayya kuenigii) sebagai Hepatoprotektor pada Tikus Putih Galur Sprague Dawley. Bogor: Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor.

Katiyar, D., Singh, V., & Ali, M. (2016). Recent advances in pharmalogical potential of Syzygium cumini: A Review. Adv. Appl. Sci. Res, 7(3),1-12.

Kumawat, M., Damor, J., Kachchhwaha, J., Garg, A. K., and Singh, C. (2018). Pharmacological properties and therapeutic potential of Syzygium cumini (Jamun): A review. World Journal of Pharmaceutical Sciences, 7, 312–322.

Kusumawati, AH., Farhamzah, F., Alkandahri, MY., Sadino, A., Agustina, LS., and Apriana, SD. (2021). Antioxidant Activity and Sun Protection Factor of Black Glutinous Rice (Oryza sativa var. glutinosa). Tropical Journal of Natural Product Research. 5(11): 1958-1961.

Lu, frank. Toksikologi Dasar. Jakarta. UI-Press. 2010.

Nahid, S., Mazumder, K., Rahman, Z., Islam, S., Rashid, M. H., Kerr, P. G. (2016). Cardio- and hepato-protective potential of methanolic extract of Syzygium cumini (L.) Skeels seeds: A diabetic rat model study. Asian Pacific Journal of Tropical Biomedicine. 7(2): 126–133

Ningrum, L. P., Salim, N., Balqis, U. (2017). Pengaruh Ekstrak Daun Jamblang (Syzygium cumini L) terhadap Histopatologi Hepar Tikus Putih (Rattus Norvegicus) Diabetes Melitus. JIMVET. 01(4):695-701.

Raza, A., Butt, M. S., & Suleria, H. A. R. (2017). Jamun (Syzygium cumini) seed and fruit extract attenuate hyperglycemia in diabetic rats. Asian Pacifics Journal of Tropical Biomedicine, 7(8), 750-754.

Rohmaniyah, K. F. (2017). Penentuan Model Klasifikasi dan Kandungan Fitokimia Ekstrak Methanol Daun Juwet (Syzygium cumini) di Madura, Jember, dan Malang Menggunakan Metode NIR dan Kemometrik. Fakultas Farmasi, Universitas Jember.

Sari, R. P. (2011). Efek Hepatoprotektor Ekstrak Biji Buah Jamblang (Syzygium cuminil). Denta Jurnal Kedokteran Gigi. 5(2): 1907-5987.

Silalahi, M. (2018). Jamblang (Syzygium cumini (L.) dan Bioaktivitasnya. Jurnal Ilmu Kesehatan. 7(2).

Sumayyah, S., & Salsabila, N. (2017). Obat Tradisional: Antara Khasiat dan Efek Sampingnya. Majalah Farmasetik, 2(5), 1-4.

Widjaja, E. A., Rahayuningsih, Y., Rahajoe, J. S., Ubaidillah, R., Maryanto, I., Walujo, E. B., & Semiadi, G. (2014). Kekinian keanekaragaman hayati Indonesia. 2014. LIPI Press.

Zarwin, A. O., Rita, R. S., Desmawati. (2020). Efek Proteksi Pemberian Ekstrak Daun Jamblang (Syzygium cumini) pada Tikus yang diinduksi Timbal Asetat. JIKESI: Jurnal Ilmu Kesehatan Indonesia. 1(2).