AKTIVITAS ANTIJAMUR EKSTRAK ETANOL DAUN KARI TERHADAP Candida albicans ATCC 14053
Abstract
Medicinal plants are recognized as valuable sources of secondary metabolites with therapeutic potential. Candidiasis caused by Candida albicans is a common health problem in tropical regions. The prolonged use of synthetic antifungal agents may lead to resistance, highlighting the need for effective natural alternatives. Curry leaves (Murraya koenigii (L) Spreng) are known to contain flavonoids and alkaloids with potential antifungal activity. This study aimed to evaluate the antifungal activity of the 96% ethanol extract of curry leaves against Candida albicans ATCC 14503. The extract was prepared by maceration using 96% ethanol as the solvent. Phytochemical screening revealed the presence of flavonoids and saponins. The antifungal activity was tested using the disc diffusion method at concentrations of 6,25%, 12,5%, 25%, and 50%. Ketoconazole was used as positive control, while 96% ethanol served as a negative control. The test was performed in triplicate, and the inhibition zones were measured and averaged. The results showed that the 96% ethanol extract of curry leaves at all tested concentrations did not exhibited antifungal activity against C. albicans as indicated by the absence of inhibition zones on the media. It can be concluded that the extract, under the given conditions, was not effective in inhibiting fungal growth. This suggests that the extraction method and tested concentrations may not have been sufficient to isolate or concentrate the active compounds. Further studies using alternative extraction techniques, higher concentrations or isolated compounds are needed to better evaluate the antifungal potential of M. koenigii.
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