KOKRISTALISASI KETOPROFEN-ASAM TARTRAT-NaCl UNTUK PENINGKATAN SIFAT KELARUTAN

Muhammad Taqiyyuddin Fahmi; Eka Deddy Irawan; Budipratiwi Wisudyaningsih; Kuni Zu’aimah Barikah; Yudi Wicaksono

doi:10.36805/jbf.v4i2.1021

Muhammad Taqiyyuddin Fahmi 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia
Eka Deddy Irawan Kelompok Riset Penghantaran Obat Fakultas Farmasi Universitas Jember, Jember, Indonesia
Budipratiwi Wisudyaningsih 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia
Kuni Zu’aimah Barikah 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia
Yudi Wicaksono 1Kelompok Riset Bahan Aktif Farmasi dan Eksipien Fakultas Farmasi Universitas Jember, Jember, Indonesia

DOI: https://doi.org/10.36805/jbf.v4i2.1021

Keywords: Ketoprofen, cocrystallization, tartaric acid, NaCl, solubility

Abstract

Ketoprofen is a drug compound with analgesic, anti-inflammatory, and antipyretic effects with very low solubility. The research aims to increase the solubility of ketoprofen using the cocrystallization method. Cocrystallization was carried out using a solvent evaporation method using a tartaric acid coformer and adding the inorganic salt NaCl. Cocrystal solids were characterized using PXRD, DSC, FTIR, and SEM. The cocrystals were evaluated for their solubility and dissolution in distilled water. The characterization results show that the ketoprofen-tartaric acid-NaCl cocrystal solid is a crystalline solid with different solid properties than the solid starting materials of ketoprofen and tartaric acid. Ketoprofen-tartaric acid-NaCl cocrystals showed significantly higher ketoprofen solubility and dissolution (p<0.05) than initial ketoprofen solubility and dissolution

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