UJI KARAKTERISTIK FISIK NANOSTRUCTURED LIPID CARRIER RESVERATROL DENGAN VARIASI SURFAKTAN PEG-7 GLYCERYL COCOATE DAN TWEEN 20

doi:10.36805/jpx.v10i1.10165

Authors

Dita Nurlita Rakhma Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Hang Tuah, Surabaya, Jawa Timur, Indonesia ,
Mariana Nur Hamidah Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Hang Tuah, Surabaya, Jawa Timur, Indonesia ,
Yuyun Nailufa Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Hang Tuah, Surabaya, Jawa Timur, Indonesia ,
Yuli Ainun Najih Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Hang Tuah, Surabaya, Jawa Timur, Indonesia ,

DOI:

https://doi.org/10.36805/jpx.v10i1.10165

Keywords:

RSV, Nanostructured lipid carrier, PEG-7 glyceryl cocoate, Tween 20

Abstract

Resveratrol (RSV) is a polyphenol compound that has been known to have antioxidant activity. However, the weakness of RSV, which has low solubility and is sensitive to light, is a limitation to be developed as a topical product. Therefore, modification of the delivery system, such as Nanostructured Lipid Carrier (NLCs), is needed to overcome this. This study aims to determine the effect of the ratio of PEG-7 Glyceryl Cocoate (GC) and Tween 20 surfactants on the physical characteristics of the RSV NLC system. In this study, the RSV NLC system was made using the High Shear Homogenization (HSH) Method with PEG-7 GC and Tween 20 surfactants in three formulas, F1 (3:9), F2 (3:12), and (3:15), and then the physical characteristics of the RSV NLC system were tested, including organoleptic, emulsion type, pH, viscosity, particle size, polydispersity index (PDI), zeta potential (ZP). The results of the physical characteristics test obtained showed that all formulas met the skin pH range. The highest viscosity sequence is (853.33 ± 20.81 nm) > F2 (793.33 ± 20.81 nm) > F1 (713.33 ± 61.10 nm). The largest particle size is F3 (308.55 ± 11.66) > F2 (270.1 ± 18.95) > F1 (216.05 ± 8.98), PDI F3 (0.26 ± 0.00) > F2 (0.25 ± 0.03) > F1 (0.22 ± 0.04). From these results it is known that the surfactant ratio affects the physical characteristics of NLC RSV.

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