AKTIVITAS ANTIPIRETIK DARI BEBERAPA SENYAWA AKTIF
Abstract
Demam merupakan suatu keadaan dimana terjadi kenaikan suhu di atas normal. Pengobatan demam biasanya menggunakan obat-obatan sintesis yang memungkinkan terjadinya resistensi. Untuk mencegah hal itu para peneliti mulai mencari kandidat senyawa obat antipiretik baru yang berasal dari bahan alam yang telah terbukti secara ilmiah memiliki aktivitas antipiretik. Beberapa senyawa aktif yang berhasil di isolasi dari berbagai tumbuhan diantaranya kurkumin, quercetin, kaempferol, piperin, asam betulinat, andrographolide dan catechin telah teruji secara ilmiah memiliki aktivitas antipiretik dengan mekanisme kerja yang berbeda-beda.
References
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Anief, Mof. Formulasi Obat Topical Dengan Dasar Penyakit Kulit. Cetakan Pertama. Yogyakarta: Penerbit Gadjah Mada University Prees. 1997.
Arifullah M, Nasma MD, Mandal M, Chiruvella KK, Vikrama P, Gopal GR, et al. Evaluation of anti-bacterial and anti-oxidant potential of andrographolide and echiodinin isolated from callus culture of Andrographis paniculata Nees. Asian Pac J Trop Biomed. 2013; Aug; 3(8): h 604–610.
Azam MG, Noman MS, Al-Amin MM, et al. Phytochemical Screening and Antipyretic Effect of Curcuma zedoaria Rosc. (Zingiberaceae) rhizome. British Journal of Pharmaceutical Research 2014; 4(5): h 569-575.
Bae J, Kim N, Shin Y, Kim S.Y, Kim Y.J, et al. Activity of Catechins and Their Applications. Biomedical Dermatology 2020; 4(8): h 1-10
Botting R, Ayoub S.S. COX-3 and the mechanism of action of paracetamol/ acetaminophen. Prostaglandins, Leukotrienes & Essential Fatty Acids 2005; 72: h 85-87.
Caceres DD, Hancke JL, Burgos RA, Wikman GK. Prevention of common colds with Andrographis paniculata dried extract. A Pilot double blind trial. Phytomedicine 1997; 4 (2): h 101-104.
Calderón-Montaño J.M, Burgos-Morón E, Pérez-Guerrero C, López Lázaro M. A, et al. Review on the Dietary Flavonoid Kaempferol. Mini Rev Med Chem 2011; 11(4): h 298-344.
Chandrasekharan N.V. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proc. Nat. Acad. Sci. USA 2002: 99; h 13926–13931.
Cheong E, Ivory K, Doleman J, Parker M.L, Rhodes M, Johnson I.T , et al. 2004, Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest. Carcinogenesis, 25, 10 pp, 1945-1952.
Cimpello LB, David LG, Henin K. 2000. Fever Pathophysiology. New York (USA): W.B. Saunders Company.
Dalal S, Zhukovsky D. S. Pathophysiology and management of fever. J Support Oncol 2006: 4(1); h 9-16.
Deng WL. Outline of current clinical and pharmacological research on Andrographis paniculata in China. Newsletters Chinese Herbal Medicine. 1978;10; h 27–31
Dey YN, Kumari S, Ota S, Srikanth N. Phytopharmacological review of Andrographis paniculata (Burm.f) Wall. exNees. Int J Nutr Pharmacol Neurol Dis 2013; 3: h 3-10
Fahryl N, Carolia, N. Kunyit (Curcuma domestica Val) sebagai Terapi Artritis Gout. Jurnal Majority 2019: 8(1); h 251- 255.
Fitoni C.N, Asri M.T, dan Hidayat, M.T. Effect of Heating of Tumeric Filtrate (Curucuma longa) on the Colony Growth of Bacteria Coliform In Vitro. Lentera Bio, 2013; 2(3): pp h 217-221.
Hesti W.S, Uning, EM, Puspitaningrum, I. Uji Efek Analgetik Antipiretik Ekstrak Etanol Alfalfa (Medicago Sativa) Pada Tikus Putih Jantan Galur Wistar. Semarang. Fakultas Farmasi Universitas Wahid Hasyim 2015: ISBN:h 978-602-19556-2-8
Ilmi H, Pamungkas IR, Tumewu L, Hafid AF, Widyawaruyanti A. Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of Andrographis paniculata in Animal Models. Evid Based Complement Alternat Med. 2021; 2021: 8848797.
Iptek, 2005. Kandungan Kimia Cabe Jawa http://www.iptek.net.id/ind/pd_ta nobat/view.php?id=108 tgl 23 Januari 2008
Jadid N. dkk. Proximate composition, nutritional values and phytochemical screening of Piper retrofractum Vahl. Fruits 2018; 8(1): p. 37-43.
Jarukamjorn K, Nemoto N. Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolide. Journal of Health Science. 2008; 54(4): h 370–381. doi: 10.1248/jhs.54.370.
Jayakumar T, Hsieh CY, Lee JJ, and Sheu JR. Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide.
Jusuf, E. Quercetin Content And Proteomic Profile Of Gvxva (Psidium Guajava L.) Varieties Wild Growing In Cibinong, Bogor. Berita Biologi. 2010: 10(3); h 401-415.
Kar A. Farmakognosi dan Farmakobioteknologi, Terjemahan: July Manurung dkk., Penerbit Buku Kedokteran EGC, Jakarta. 2014: 2 (2); h 503-504.
Kimura Y, Sumiyoshi M, Kawahira K, dan Sakanaka M. Effects of Ginseng Saponins Isolated from Red Ginseng Roots on Burn Wound Healing in Mice. British Journal of Pharmacology; 2006; 148: pp: 860-870.
Kolhe S.R, Borole P, and Patel U. Extraction and Evaluation of Piperine from Piper nigrum, Internasional Journal of Applied Biology and Pharmaceutical Technology, 2011; h144-149.
Kusumaningrum, Y.I. 2008. Hubungan antara Pengetahuan Ibu dan Faktor-Faktor Sosial ekonomi Orangtua dengan Praktik Pemberian Makanan Pendamping ASI (MP-ASI) pada Bayi Usia 6-12 Bulan di Desa Kemuning Kecamatan Ampel gading Kabupaten Pemalang (Doctoral dissertation, Universitas Negeri Semarang).
Lakhanpal P, Rai K.D, Quercetin: A Versatile Flavonoid. Internet Journal of Medical Update, 2007; 2(2): h 22-37. (Picture).
Madav S, Tripathi HC, Tandan, Mishra SK. Analgesic, antipyretic and antiulcerogenic effects of andrographolide. Indian Journal of Pharmaceutical Sciences. 1995; 57(3): h 121–125.
Malik F, Ningsi A, Bafadal M, Saktiani D.N, Wahyuni, et al. Antipyretic Effect Test of Wualae Fruit Ethanol Extract (Etlingera elatior (Jack) R.M. Smith) Against Male Mice (Mus musculus L.) Balb/C strain. Pharmauho, 2018; 4(1): h 9-11
Marbawati D, Umniyatim S.R. Uji Anti Virus Senyawa Kurkumin dan PGV-0 pada Virus Dengue-2 Dengan RT-PCR. BALABA, 2016: 12(1); pp.15-22.
Middleton E, Kandaswami C, Theoharides TC. The effects of plant flavonoid on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000; 52: h 673-751.
Mulyani S, Harsojuwono B.A, Puspawati, G.A.K.D. Potensi Minuman Kunyit Asam (Curcuma domestica Val. - Tamarindus indica L.) Sebagai Minuman Kaya Antioksidan. Agritech, Mutiah, R. (2015). Evidence Based curcumin Dari Tanaman Kunyit (Curcuma longa) Sebagai Terapi Kanker Pada Pengobatan Modern. Jurnal Farma Sains, 2014: 1(1); pp. 28-41.
Mutia V, Oktarlina R.Z. The Effectivity Ricinus Communis L. Leaf As An Anti-pyretic. Majority, 2017: 7(1); h 36-40.
Ningsih D, Sri RE, Assessment of Antypiretic Activity and Total Flavonoid Contents of Carica papaya, L. leaf Extract. Jurnal Farmasi Indonesia, 2018:15(2); h 101-108.
Nisar A, Hina F, Bilal H, Shahid F, Mohammad A, and Mubarak A. Biological role of Piper nigrum L., (Black pepper): A Review. Asian Pacific Journal of Tropical Biomedicine 2012; 10: h 1-10.
Noreen Y, Ringbom T, Perera P, Danielson H, Bohlin L, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay, for identification of natural products as inhibitors of prostaglandin biosynthesis. Pubmed, 1998; 61(1): h 2–7.
Oyebanji BO, Saba A, Oridupa OA. Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from Tetracera Potatoria.. African Journal of Traditional, Complementary and Alternative Medicines, 2013: 11(1); -.doi:10.4314/ajtcam.v11i1.5
Okhuarobo A, Ehizogie Falodun J, Erharuyi O, Imieje V, Falodun A, Langer P. Harnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology. Asian Pacific Journal of Tropical Disease. 2014; 4(3): h213–222. doi: 10.1016/s2222-1808(14)60509-0.
Patel SR, Bharti S, Pratap CB, Nath G. Drug resistance pattern in the recent isolates of Salmonella typhi with special reference to cephalosporins and azithromycin in the gangetic plain. J Clin Diagnostic Res. 2017; 11(6): h 1–3.
Robert H. Cichewicz; Samir A. Kouzi. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. 2004: 24(1); h 90–114. doi:10.1002/med.10053
Sabina E.P, Nasreen A, Vedi M, and Rasool M. Analgesic, Antipyretic and Ulcerogenic Effects of Piperine: An Active Ingredient of Pepper, Journal of Pharmaceutical Sciences and Research, 2013; 5 (10): h 203-206.
Schmitt, b.d. fever in childhood. 1984.
Sen G, Sarkar N, Nath M, Maity S. Bioactive Components of Tea. Arch Food Nutr Sci, 2020; 4: h 001-009
Serafini M, Peluso I, Raguzzini A. Flavonoids as anti – inflammatory agents. Proceedings of the Nutrition Society. 2010; 69(3): h273-8.
Sherwood, L. 2012. Fisiologi Manusia dari Sel ke Sistem. Edisi 6. Jakarta : EGC.
Sherwood, L. Fisiologi Manusia; dari Sel ke Sistem. Edisi 2. Jakarta: EGC. 2001.
Sianipar E. A, Louisa M, dan Wanandi, S.I. Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara terhadap Takmoksifen Melalui Penghambatan Ekspresi P- glikoprotein dan Breast Cancer Resistance Protein. Jurnal Farmasi Galenika, 2018; 4(1): h-11.
Siddiqui S. A, Rahman A, Rahman M. O, Akbar M. A, Ali M. A, Al-Hemaid F. M. A, Farah M. A. et al. A novel triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata attributes multi-faced pharmacological activities. Saudi Journal of Biological Sciences. doi:10.1016/j.sjbs.2018.03.002
Silbernagl S, & Lang, F. Gangguan Metabolisme Lipoprotein. Teks dan Atlas Berwarna Patofisiologi, 14th edn, Jakarta 2013: h 246-49.
Simanjuntak, Partomuan dan Murwani, Retno 20023. Isolasi dan Identifikasi Senyawa Aktif Anti Tumor dari Ekstrak Daun Benalu The (Scumsla Oortiana), Dokumentasi Lembaga Penelitian.
Sudjarwo S. A. 2006, The potency of piperine as antiinflammatory and analgesic in rats and mice, Folia medica Indonesiana, 2006 : 41(3); h 190-4.
Suebsasana S, Pongnaratorn P, Sattayasai J, Arkaravichien T, Tiamkao S, Aromdee C. Analgesic, antipyretic, anti-inflammatory and toxic effects of andrographolide derivatives in experimental animals. Archives of Pharmacal Research. 2009; 32(9): h1191–1200. doi: 10.1007/s12272-009-1902-x.
Suryasaputra D, Anugrah R, Ikhsan A, Rismaya. Quantitative Structure-Activity Relationship, Molecular Docking And In Vitro Study Of Several Flavonoids As COX-2 Inhibitors. Farmasains, 2019; 6(1): h 27-33.
Tijani AY, Uguru MO, Salawu OA. Anti-pyretic, anti-inflammatory and anti-diarrhoeal properties of Faidherbia albida in rats. Afr J Biotech. 2008; 7(6): h 696–700.
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Published
2021-09-30
Section
Articles
