LITERATURE REVIEW: POTENSI FRAKSINASI PROPOLIS LEBAH KELULUT SEBAGAI PENELUSURAN AGEN ANTIDIABETES
Abstract
Diabetes mellitus is a metabolic disorder characterised by hyperglycaemia caused by abnormalities in insulin secretion and insulin action. Indications that arise in people with diabetes include polyuria, hyperphagia and polydipsia. Propolis or bee glue is a product made from plant sources by bees. This study aims to recognise the potential of propolis as an antidiabetic agent in diabetes mellitus. The research method in the literature study by applying journal searches on Google Scholar, PubMed, and ResearchGate databases published in 2010-2024. Based on the results of the article search, 7 suitable journals were identified. These articles consisted of 7 experimental articles. The results showed that propolis can be used as an effective antidiabetic agent to control blood glucose levels, repair damage to the islets of Langerhans, suppress oxidative stress and as an anti-inflammatory. Active compounds contained in kelulut bee propolis such as flavonoids and also other compounds such as phenolics, polyphenols and caffeic acid phenethyl ester (CAPE) compounds. It is also known that propolis treatment can reduce diabetic complications such as nephropathy, retinopathy, leg ulcers, and liver disease. propolis has great potential as a natural antidiabetic drug. The secondary metabolites in propolis, such as flavonoids, terpenoids and saponins, provide various properties including protecting pancreatic β-cells, reducing insulin resistance, and reducing oxidative stress. Fractionation can be one method of exploring the potential of propolis as an antidiabetic.
References
Advistasari, Y.D., Vifta, R.L., 2018. Uji Antidiabetes Ekstrak Etanol Buah Parijoto (Medinilla Speciosa B.) Dan Fraksinya. Media Farm. Indones. 13. https://doi.org/https://mfi.stifar.ac.id/MFI/article/view/88
Al-Snafi, A.E., 2021. Medicinal plants alkaloids, as promising therapeutics-A review (part 1). IOSR J. Pharm. 11, 51–67.
Anvarifard, P., Anbari, M., Ostadrahimi, A., Ardalan, M., Ghoreishi, Z., 2022. A comprehensive insight into the molecular and cellular mechanisms of the effects of Propolis on preserving renal function: A systematic review. Nutr. Metab. (Lond). 19.
Balica, G., Vostinaru, O., Stefanescu, C., Mogosan, C., Iaru, I., Cristina, A., Pop, C.E., 2021. Potential Role of Propolis in the Prevention and Treatment of Metabolic Diseases. Plants 10. https://doi.org/https://doi.org/10.3390/plants10050883
Batistuta, M.A., Zulfa, A.F., Kustiawan, P.M., 2022. Aktivitas Antioksidan Fraksi N-Heksan Propolis Lebah Kelulut (Geniotrigona thoracica). Med. Sains J. Ilm. Kefarmasian 7, 217–224.
de Medeiros, G.V.D., da Silva Teófilo, T., Salatino, A., Negri, G., Jara, C.E., Viana, G.A., Costa, W.P., Freitas, C.I.A., de Menezes, M.C., de Morais, M.C.B., Moura, G.H.F., Rodrigues, V.H.V., Batista, J.S., 2021. Evaluation of the Potential of Brazilian Red Propolis in the Acceleration of Healing in Surgical Wounds. Nat. Prod. J. 11, 522–531. https://doi.org/10.2174/2210315510999200613234622
Efriani, L., Hadi, I., Irawan, A., Ulfah, M., Adiyas Putra, T., 2023. UJI AKTIVITAS INHIBISI ENZIM a-Glukosidase TERHADAP EKSTRAK ASETON, ETANOL, DAN METHANOL DAUN MANGROVE (Rhizopora Mucronata) SEBAGAI ANTIDIABETES. Med. Sains J. Ilm. Kefarmasian 8, 1371–1378. https://doi.org/10.37874/ms.v8i4.651
Ibrahim, N., Niza, N.F.S.M., Rodi, M.M.M., Zakaria, A.J., Ismail, Z., Mohd, K.S., 2016. Chemical and biological analyses of Malaysian stingless bee propolis extracts. Malaysian J. Anal. Sci. 20, 413–422.
Ibrahim, N., Mohd Niza, N.F.S., Mohd Rodi, M.M., Zakaria, A.J., Ismail, Z., Mohd, K.S., 2016. Chemical And Biological Analyses Of Malaysian Stingless Bee Propolis Extracts. Malaysian J. Anal. Sci. 20, 413–422.
Kitamura, H., 2019. Effects of propolis extract and propolis-derived compounds on obesity and diabetes: knowledge from cellular and animal models. Molecules 24, 4394.
Kustiawan, P.M., Aziz, A., Yuliawan, V.N., 2022. Antioxidant and Antibacterial Activity of Various Fractions of Heterotrigona itama Propolis Found in Kutai Kartanegara. Open Access Maced. J. Med. Sci. 10, 531–534.
Kustiawan, P.M., Luthfi M, C.F.M., Dewi, S.R., Pratiwi, J., Aisyiyah, N.M., Nugraha, A.S.D., Setiawan, I.M., 2023. Phytochemical Analysis and Anti-Inflammatory Activity of The Combination of Trigona apicalis propolis Extract and Honey. Borneo J. Pharm. 6, 125–132. https://doi.org/10.33084/bjop.v6i2.4696
Laratmase, R. V., Katja, D.G., Momuat, L.I., 2024. Potensi Antidiabetes Ekstrak Metanol dan Fraksi dari Kulit Batang Chisocheton sp. (C.Dc) Harms pada Tikus Putih (Rattus norvegicus). Chem. Prog. 17.
Lim, O.Z., Yeoh, B.S., Omar, N., Mohamed, M., Zin, A.A.M., Ahmad, R., 2022. Stingless bee propolis, metformin, and their combination alleviate diabetic cardiomyopathy. Brazilian J. Pharm. Sci. 58.
Lima, V.H.M., Almeida, K.C.R., Alves, C.C.F., ..., 2020. Biological properties of volatile oil from Brazilian brown propolis. Rev. Bras. ….
Magliano, D., Boyko, E.J., 2021. IDF diabetes atlas (10th edition), in: International Diabetes Federation.
Maisarah, M., Chatri, M., 2023. Karakteristik dan Fungsi Senyawa Alkaloid sebagai Antifungi pada Tumbuhan. J. Serambi Biol. 8. https://doi.org/https://doi.org/10.24036/srmb.v8i2.205
Musfiroh, I., Syifa, K.A., Muhtadi, A., 2020. Uji Antidiabetes Fraksi Air, Etil Asetat Dan N-Heksan Buah Mengkudu (Morinda Citrifolia L.) Pada Tikus Putih Metode Induksi Aloksan. J. Farm. Galen. 7.
Negri, G., Salatino, A., Pereira, L.L.R., Salatino, M.L.F., ..., 2022. A highly complex stingless bee propolis: Composition and influence of the period of collection. JSFA …. https://doi.org/10.1002/jsf2.29
Ningsih, I.S., Chatri, M., Advinda, L., 2023. Flavonoid Active Compounds Found In Plants Senyawa Aktif Flavonoid yang Terdapat Pada Tumbuhan. SERAMBI Biol. 8, 126–132.
Nishikawa, S., Hydo, T., Aoyama, H., Miyata, R., Kumazawa, S., Tsuda, T., 2020. Artepillin C, a Key Component of Brazilian Propolis, Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through a Creatine-Metabolism-Related Thermogenic Pathways. J. Agric. Food Chem. 68, 1007–1014.
Nna, V.U., Abu Bakar, A.B., Ahmad, A., Eleazu, C.O., Mohamed, M., 2019. Oxidative stress, NF-κb-mediated inflammation and apoptosis in the testes of streptozotocin–induced diabetic rats: Combined protective effects of malaysian propolis and metformin. Antioxidants 8, 465.
Pratama, M., Muflihunna, A., Octaviani, N., 2018. Analisis Aktivitas Antioksidan Sediaan Propolis Yang Beredar Di Kota Makassar Dengan Metode Frap (Ferric Reducing Antioxidant Power). As-Syifaa J. Farm. 10.
Rahayuningsih, N., 2020. Aktivitas Antidiabetika Beberapa Fraksi Ekstrak Daun Alpukat (Persea Americanna Mill) Pada Tikus Putih Jantan Dengan Induksi Aloksan. J. Kesehat. Bakti Tunas Husada J. Ilmu-ilmu Keperawatan, Anal. Kesehat. dan Farm.
Ribeiro, V.P., Mejia, J.A.A., Rodrigues, D.M., Alves, G.R., de Freitas Pinheiro, A.M., Tanimoto, M.H., Bastos, J.K., Ambrósio, S.R., 2023. Brazilian Brown Propolis: an Overview About Its Chemical Composition, Botanical Sources, Quality Control, and Pharmacological Properties. Rev. Bras. Farmacogn. 33, 288–299. https://doi.org/10.1007/s43450-023-00374-x
Rizky, M., 2022. Uji Antiinflamasi Kombinasi Madu dan Propolis Lebah Kelulut (Heterotrigona itama) pada Mencit (Mus musculus). https://doi.org/https://dspace.umkt.ac.id//handle/463.2017/3343
Rosyidi, D., Radiati, L.E., Minarti, S., Mustakim, M., Susilo, A., Jaya, F., Azis, A., 2018. Perbandingan Sifat Antioksidan Propolis pada Dua Jenis Lebah (Apis mellifera dan Trigona sp.) di Mojokerto dan Batu, Jawa Timur, Indonesia. J. Ilmu dan Teknol. Has. Ternak 13, 108–117.
Sagita, P., 2021. Pengaruh Pemberian Daun Sirsak (Annona muricata) Terhadap Penyakit Diabetes Melitus. J. Med. Hutama 3, 1265–1272.
Santos, F.A., Bastos, E., Maia, A., Uzeda, M., ..., 2003. Brazilian propolis: physicochemical properties, plant origin and antibacterial activity on periodontopathogens. Phyther. …. https://doi.org/10.1002/ptr.1117
Sari, A.N., Ramadhani, E.P., Ahmad, R., 2015. Potensi Propolis Sebagai Antidiabetes Berdasarkan Analisis Sayatan Histologi Pankreas. Elkawnie J. Islam. Sci. Technol. 1. https://doi.org/https://doi.org/10.22373/ekw.v1i2.344
Silva, F.R.G., Matias, T.M.S., Souza, L.I.O., ..., 2018. Phytochemical screening and in vitro antibacterial, antifungal, antioxidant and antitumor activities of the red propolis Alagoas. Brazilian J. ….
Sinaga, F.A., 2016. Stress Oksidatif dan Status Antioksidan pada Aktivitas Fisik Maksimal. J. Gener. Kampus 9, 176–189.
Tiang, H.S., Qin, L., Liu, T., Yang, X., Qi, Z., Qin, H., ..., Wu, L., 2025. Exploring the therapeutic potential of propolis in managing diabetes: a preclinical study. J. Tradit. Chinese Med. Sci.
Tran, T.D., Ogbourne, S.M., Brooks, P.R., ..., 2020. Lessons from exploring chemical space and chemical diversity of propolis components. Int. J. ….
Tumiwa, N.N.G., Manawan, F., 2022. Aktivitas Antidiabetes Fraksi-Fraksi Ekstrak Daun Yacon (Smallanthus sonchifolius) dan Ekspresi Protein GLUT-4 Jaringan Otot Soleus pada TikusResistensi insulin, in: Prosiding Seminar Nasional Kefarmasian.
Utami, I.K., 2019. Uji Aktivitas Antidiabetes Ekstrak Etanol Propolis Pada Mencit Putih Jantan Galur Balb /C Dengan Induksi Aloksan. Farmakol. J. Farm. XVI, 194–201.
Woźniak, M., Mrówczyńska, L., Kwaśniewska-Sip, P., Waśkiewicz, A., Nowak, P., Ratajczak, I., 2020. Effect of the solvent on propolis phenolic profile and its antifungal, antioxidant, and in vitro cytoprotective activity in human erythrocytes under oxidative stress. Molecules 25, 4266.
Yanuar, M.R.S., Raharja, A., Rollando, R., 2025. Penapisan Senyawa dari Rempah-rempah khas Indonesia Terhadap MMP9 dan TNFα sebagai target penyembuh Luka Diabetes Dengan Metode Penambatan Molekul. J. Farmamedika (Pharmamedika Journal) 10, 46–53.
Yao, Y., Cai, X., Fei, W., Ye, Y., Zhao, M., 2022. The role of short-chain fatty acids in immunity, inflammation and metabolism. Crit. Rev. Food Sci. Nutr. 62, 1–12. https://doi.org/https://doi.org/10.1080/10408398.2020.1854675
Yuliawan, V.N., Aziz, A., Kustiawan, P.M., 2021. Uji fitokimia fraksi etil asetat dari propolis lebah kelulut Heterotrigona itama asal Kutai Kartanegara. Lumbung Farm. J. Ilmu Kefarmasian 2, 131–137.
Yusransyah, Y., Stiani, S.N., Sabilla, A.N., 2022. Hubungan Antara Kepatuhan Minum Obat Pasien Diabetes Mellitus dan Support yang Diberikan Keluarga. J. Ilm. Kesehat. Delima 4, 74–77. https://doi.org/https://doi.org/10.60010/jikd.v4i2.79
Yusuf, A.P., Zhang, J.Y., Li, J.Q., Muhammad, A., Abubakar, M.B., 2022. Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges. Phytomedicine plus 2, 100280.
Zulfa, A.F., Batistuta, M.A., Kustiawan, P.M., 2022. Aktivitas Antibakteri Fraksi Etil Asetat Dari Propolis Lebah Kelulut Geniotrigona thoracica Terhadap Bakteri Staphyloccocus aureus. J. Ilmu Kefarmasian 3, 215–220.
