AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KRATOM (Mitragyna speciosa Korth.) TERHADAP BEBERAPA BAKTERI PENYEBAB JERAWAT
Abstract
Acne is a common disease on the surface of the skin of the face. It will appear when the oil glands are too active and is generally followed by a bacterial infection that will cause inflammation. Bacteria that can cause acne include Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The plant that has antibacterial activity is kratom (Mitragyna speciosa Korth). Kratom leaves have secondary metabolites that can act as antibacteria, such as alkaloids, flavonoids, and saponins. The study aims to determine the antibacterial activity of ethanol extract against some bacteria causing acne using disc diffusion methods. The concentrations of the test sample ethanol extract of kratom leaves used were 60%, 30%, 15%, and 12.5%, with the positive controls used being chloramphenicol. The results of the study showed that ethanol extract at all concentrations had a barrier zone against the growth of the bacteria P. acnes, S. aureus, and S. epidermidis with a moderate barrier response category. Where best activity is shown at a concentration of 60% kratom leaf ethanol extract against P.acnes and S.aureus
References
Alkandahri, MY., Kusumawati, AH., and Fikayuniar, L. Antibacterial Activity of Zingiber officinale Rhizome. International Journal of Psychosocial Rehabilitation. 2020; 24(1): 8604-8608.
Anindita PR, Setyawati H, Wahyuni KI, Putri DO, Ambari Y. Uji Sediaan Krim Ekstrak Daun Kratom (Mitragyna speciosa Korth.) yang Berpotensi sebagai Antinosiseptif pada Mencit Jantan Galur DDY. Jurnal Pharmascience. 2023; 10(1).
Arfania, M., Frianto, D., Astuti, D., Anggraeny, EN., Kurniawati, T., Alivian, R., Alkandahri, MY. Measurement of Adherence Level of Pulmonary Tuberculosis Drugs use in Patients in the Primary Health Centers in Karawang Regency, West Java, Indonesia, using MMAS Instrument. Journal of Pharmaceutical Research International. 2021; 33(54A):115-120.
Aulia DR, Muthmainah N, Yasmina A. Perbandingan Aktivitas Antibakteri Ekstrak Daun Tanjung dan Daun Jambu Biji terhadap Salmonella typhi In Vitro. Homeostasis. 2020; 3(1), 7–17.
Ervianingsih E, Razak A. Uji Daya Hambat Ekstrak Daun Kucai (Allium schoneoprasum L.) terhadap Pertumbuhan Stretococcus mutans. Jurnal Mandala Pharmacon Indonesia, (2017); 3(2).
Fikayuniar L, Waldani DP, Lidia I, Wahyuningsih ES. Uji Aktivitas Antibakteri Pada Ekstrak Biji Kurma Ajwa (Phoenix dactylifera L.) Terhadap Bakteri Staphylococcus aureus. Journal of Pharmacopolium, 2022; 5(2), h:148–154.
Hakim AR, Saputri R. Narrative Review: Optimasi Etanol Sebagai Pelarut Senyawa Flavonoid dan Fenolik. Jurnal Surya Medika. 2020; 6(1), h: 177–180.
Iksan H, Frianto D, Alkandahri MY. Evaluasi Pengobatan Infeksi Saluran Pernapasan Akut Pada Balita Di Klinik X Cikarang Utara. Jurnal Buana Farma: Jurnal Ilmiah Farmasi. 2021;1(3):31-36.
Jawetz E, Melnick JL, Adelberg EA, Brooks GF, Butel JS, Ornston LN. Mikrobiologi kedokteran. 2005; Penerbit: EGC.
Kursia S, Lebang JS, Taebe B, Burhan A, Rahim, WOR, Nursamsiar. Uji Aktivitas Antibakteri Ekstrak Etilasetat Daun Sirih Hijau (Piper betle L.) terhadap Bakteri Staphylococcus epidermidis. Indonesian Journal of Pharmaceutical Science and Technology, Volume 3, Nomor 2, 2016.
Kusumawati, AH., Farhamzah, F., Alkandahri, MY., Sadino, A., Agustina, LS., and Apriana, SD. Antioxidant Activity and Sun Protection Factor of Black Glutinous Rice (Oryza sativa var. glutinosa). Tropical Journal of Natural Product Research. 2021; 5(11): 1958-1961.
Nur S, Zulkarnain. Jerawat (Acne vulgaris): Review Penyakit Infeksi pada Kulit. Prosiding Biologi Achieving the Sustainable Development Goals with Biodiversity in Confronting Climate Change. 2021
Nurhayati LS, Yahdiyani N, Hidayatulloh A. Perbandingan Pengujian Aktivitas Antibakteri Starter Yogurt dengan Metode Difusi Sumuran dan Metode Difusi Cakram. Jurnal Teknologi Hasil Peternakan, 2020; 1(2), h:41.
Rahman GTP, Fitriyana M. Uji Aktivitas Antibakteri Daun Srikaya (Annona squamosa L.) Terhadap Pertumbuhan Bakteri Penyebab Jerawat Propionibacterium acnes. Journal of Herb Farmacological HerbaPharma, 2023; 5(2), h:122–130.
Ratu DR, Fifendy M, Advinda L. The Effect of Various Concentrations of Antiacne Liquid Soap on The Bacteria of Staphylococcus aureus Causes Acne. Serambi Biologi, 2022; 7(4), h: 311–317.
Suhaimi S, Puspasari H, Husnani H, Apriani M. Aktivitas Antibakteri Ekstrak Daun Kratom (Mitragyna speciosa Korth) Terhadap Bakteri Propionibacterium acnes Sebagai Penyebab Jerawat. Medical Sains, 2019; 4(1).
Tristiyanti D, Herawati IE, Kartikawati E. Perbandingan Aktivitas Antibakteri Daun Tempuh Wiyang (Emilia sonchifolia L.) dan Daun Situduh Langit (Erigeron sumatrensis Retz.) terhadap Bakteri Propionibacterium acnes ATCC 1223. Journal of Pharmacopolium, 2023; 6(3), 18–27.
Wahyuningsih ES, Puspitasari M, Gunarti NS, Alkandahri MY. Uji Aktivitas Antibakteri Face Mist Ekstrak Etanol Daun Andong Merah (Cordyline fruticosa (L) A. Chev.) Terhadap Propionibacterium acnes. Pharma Xplore: Jurnal Sains dan Ilmu Farmasi. 2023;8(2):104-127.
Wardani AK, Fitriana Y, Malfadinata S. Uji Aktivitas Antibakteri Penyebab Jerawat Staphylococus epidermidis Menggunakan Ekstrak Daun Ashitaba (Angelica keiskei). LUMBUNG FARMASI; Jurnal Ilmu Kefarmasian, 2020; 1(1).
