STUDI UJI AKTIVITAS ANTIINFLAMASI FRAKSI CIPLUKAN (Physalis angulata Linn.) PADA TIKUS MODEL INFLAMASI YANG DIINDUKSI PUTIH TELUR

Ratu Zalika Aulya Puteri Sudrajat; Muchamad Ramadhan Ardhi Yusuf; Aufa Aulia Dwi Putri; Shenny Syifana Surya Permana; Jasmine Yasyfa Sukmayani; Miski Aghnia Khairinisa; Indah Suasani Wahyuni; Enny Rohmawati; Muhammad Hasan Bashari; Ronny Lesmana; Aziiz Mardanarian Rosdianto

doi:10.36805/nrwrfj93

Authors

Ratu Zalika Aulya Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Muchamad Ramadhan Ardhi Yusuf Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Aufa Aulia Dwi Putri Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Shenny Syifana Surya Permana Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Jasmine Yasyfa Sukmayani Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Miski Aghnia Khairinisa Departemen Farmakologi dan Farmasi Klinik, Fakultas Farmasi, Universitas Padjadjaran Jatinangor
Indah Suasani Wahyuni Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran Jatinangor
Enny Rohmawati Departemen Ilmu Kedokteran Dasar, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Muhammad Hasan Bashari Departemen Ilmu Kedokteran Dasar, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Ronny Lesmana Departemen Ilmu Kedokteran Dasar, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor
Aziiz Mardanarian Rosdianto Departemen Ilmu Kedokteran Dasar, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor , Program Studi Kedokteran Hewan, Fakultas Kedokteran, Universitas Padjadjaran Jatinangor

DOI:

https://doi.org/10.36805/nrwrfj93

Keywords:

acute inflammation, antiinflammation, flavonoid

Abstract

Acute inflammatory conditions such as uveitis in pets can lead to discomfort and unnecessary pain. The treatment for uveitis involves the administration of anti-inflammatory drugs, including NSAIDs or herbal remedies generally containing flavonoids. Physalis angulata Linn., known as Ciplukan, encompasses compounds exhibiting anticoagulant, antimicrobial, anti-inflammatory, and anticancer activities. Ciplukan is composed of withanolids, terpenoids, carotenoids, and flavonoids. This study was conducted to investigate the anti-inflammatory effect of the ciplukan ethyl acetate fraction (CEAF) on Wistar rats as egg white-induced inflammation models and the most effective dose. The test was carried out on 6 test groups, each consisting of 5 rats. The test groups consisted of a normal control group, a 4,5 mg/kgBW diclofenac induced group, a negative control (NC) group which were induced inflammation using egg whites, and CEAF administration at respective doses of 5, 10, and 15 mg/kgBW groups. The parameters used in this research were plant determination, phytochemical tests, measurement of edema volume, and analysis of anti-inflammatory activity. The volume of edema on the rats’ paws was measured using a plethysmometer periodically, with a total period of 6 hours. All the data in the study were analysed statistically using the One-Way Analysis of Variance (ANOVA) method and the Tukey test with 95% CI. The results indicated that the CEAF with dose of 15 mg/kgBW exhibited a percentage of edema inhibition (47,8%) closest to that of the diclofenac sodium group (61,6%). The study findings suggest that the CEAF possesses anti-inflammatory activity with the most effective dose of 15 mg/kgBW.

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