PENINGKATAN DISOLUSI ETIL P-METOKSISINAMAT MELALUI KOKRISTALISASI DENGAN ASAM TARTRAT: EVALUASI MULTI-PH UNTUK OPTIMALISASI BIOAVAILABILITAS ORAL
DOI:
https://doi.org/10.36805/h8y2bs27Kata Kunci:
Etil p-metoksisinamat, Asam tartrat, Kokristal, Disolusi, BioavailabilitasAbstrak
Etil p-metoksisinamat (EPMS) adalah senyawa bioaktif dari rimpang kencur dengan aktivitas antiinflamasi dan antikanker yang potensial sebagai kandidat obat baru. Namun, kelarutan rendah EPMS (128,1 mg/L) yang termasuk BCS kelas II membatasi laju disolusi dan bioavailabilitasnya. Penelitian ini bertujuan meningkatkan laju disolusi EPMS melalui pembentukan kokristal dengan asam tartrat, serta menentukan rasio koformer optimal dan kondisi pH yang memberikan peningkatan disolusi paling besar. Kokristal EPMS-asam tartrat dibuat menggunakan metode solvent drop grinding dengan rasio stoikiometri 1:1, 1:2, dan 1:3. Uji disolusi partikulat dilakukan menggunakan alat disolusi tipe II dalam tiga media dapar (HCl pH 1,2; asetat pH 4,5; fosfat pH 6,8) pada suhu 37±0,5°C selama 60 menit (n=3). Kokristal rasio 1:3 dalam medium HCl pH 1,2 memberikan hasil terbaik dengan peningkatan disolusi hingga 8,5 kali lipat dibandingkan EPMS murni (p<0,05). Peningkatan signifikan juga terjadi pada semua media pH yang diuji. Kokristalisasi dengan asam tartrat berhasil meningkatkan disolusi EPMS secara signifikan pada semua kondisi pH, dengan potensi meningkatkan bioavailabilitas oral EPMS sebagai kandidat obat antiinflamasi
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Hak Cipta (c) 2025 Revika Rachmaniar, Rival Ferdiansyah, Fauzan Ahmad Mudzakkir, Nela Simanjuntak
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