AKTIVITAS KAPSUL ANTIHIPERKOLESTEROLEMIA EKSTRAK ETANOL DAUN RAMBUTAN (Nephelium lappaceum L.) PADA MENCIT PUTIH JANTAN (Mus musculus)

Tsalma Dwi Juliani Fasya; Richa Mardianingrum; Nitya Nurul Nitya Nurul Fadilah

doi:10.36805/cd5b3173

Authors

Tsalma Dwi Juliani Fasya Prodi Farmasi, Fakultas Ilmu Kesehatan, Universitas Perjuangan Tasikmalaya, Jawa Barat, Indonesia.
Richa Mardianingrum Prodi Farmasi, Fakultas Ilmu Kesehatan, Universitas Perjuangan Tasikmalaya, Jawa Barat, Indonesia.
Nitya Nurul Nitya Nurul Fadilah Prodi Farmasi, Fakultas Ilmu Kesehatan, Universitas Perjuangan Tasikmalaya, Jawa Barat, Indonesia.

DOI:

https://doi.org/10.36805/cd5b3173

Keywords:

Antihypercholesterolemic, Capsule, Rambutan leaf, Simvastatin

Abstract

Hypercholesterolemia, characterized by elevated blood cholesterol, is recognized as a key risk factor for cardiovascular diseases. Statin drugs, such as simvastatin, effectively reduce cholesterol levels but may cause side effects with long-term use. Rambutan (Nephelium lappaceum L.) leaves contain flavonoid compounds that may serve as a natural antihypercholesterolemic agent. The objective of this study was to investigate the cholesterol-lowering effect of capsules containing rambutan leaf ethanol extract in male Swiss Webster mice (Mus musculus). A total of twenty-five animals were randomly allocated into five groups: a positive control (simvastatin), a negative control, and three treatment groups receiving extract doses of 10, 20, and 40 mg/kgbw. Capsule physical evaluations included flow time (8.27–8.72 seconds), angle of repose (32°–36°), compressibility (7.4–15%), moisture content (2.8–3.9%), weight uniformity (199.85–199.97 mg ± <1 mg), and disintegration time (1.09–1.86 minutes), all meeting pharmacopeial standards. Cholesterol levels were measured and statistical testing showed a significant decrease (p < 0.05) in the treatment groups compared to the negative control. The 40 mg/kgbw dose produced the highest cholesterol reduction (30.9%) and was not significantly different from simvastatin (p<0.05). These results suggest that ethanol extract capsules of rambutan leaves have potential as an alternative natural cholesterol-lowering therapy.

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