UJI AKTIVITAS ANTIJERAWAT DAN KARAKTERISTIK FISIK EMULGEL MINYAK ATSIRI DAUN JERUK PURUT (Citrus hystrix DC.) DENGAN BASIS GEL HPMC TERHADAP Propionibacterium acne

Anggun Hari Kusumawati

Abstract


ABSTRACT
Tests were conducted antiacne activity emulgel of essential kaffir lime leaves oils (Citrus hystrix DC.) against Propionibacterium acne. Antiacne activity assays performed by agar diffusion method at a concentration of 1%, 2%, 4%, and 8%. The results showed that of the kaffir lime leaves oil can inhibit the growth of P.acne. The greatest inhibitory regions shown the higher concentration of kaffir lime leaves oils, then the inhibitory of growth inhibition area P.acne increasingly widespread of 8% > 4% > 2% > 1%. Relationships increased concentration of essential lime leaves oils in the emulgel dosage effect on physical properties such as chemical emulgel pH, viscosity, and the power spread. From the test results it is known that the higher the concentration of oils in the preparation kaffir lime leaves emulgel the pH and viscosity of the lower F0> F1> F2> F3> F4, while increasing power spread F0 4% >2%>1%. Hubungan peningkatan konsentrasi minyak atsiri daun jeruk purut dalam sediaan emulgel berpengaruh terhadap sifat fisika kimia emulgel seperti pH, viskositas, dan daya sebar. Dari hasil uji diketahui bahwa semakin tinggi konsentrasi minyak atsiri daun jeruk purut dalam sediaan emulgel maka pH dan viskositas semakin rendah F0>F1>F2>F3>F4, sedangkan daya sebar semakin meningkat F0

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References


DAFTAR PUSTAKA

Agusta, A. 2000. Minyak Atsiri Tumbuhan Tropika Indonesia. Bandung : ITB.

Ansel, H.C. 2005. Pengantar Sediaan Farmasi. Jakarta: UI Press.

Cunliffe,WJ.&, Simpson, NB. 2000. Acne and Treatment. London : Champion RH. P.148-169.

Darrell, R.A. 2007. United State Pharmacopeia 30-NF 25. US : United State Phermacopeial Convention.

Depkes RI. 1995. Farmakope Indonesia. Edisi IV. Jakarta : Direktorat Jendral Pengawasan Obat dan Makanan Departemen Kesehatan Republik Indonesia. Halaman 7.

Djuanda, A. 2002. Ilmu Penyakit Kulit dan Kelamin. Jakarta: Fakultas Kedokteran Universitas Indonesia.

Garg, A., Aggarwal, D., Garg, S., & Sigla, A.K. 2002. Spreading of Semisolid Formulation: An Update, Pharmaceutical Tecnology.[serial online]. www.pharmtech.com. [24 Juni 2011].

Lachman, L., Lieberman, H.A., & J. L. Kanig. 1989a. Teori dan Praktek Farmasi Industri. Edisi ketiga. Jilid 1. Diterjemahkan oleh Siti Suyatmi. Jakarta : Penerbit Universitas Indonesia (UI-Press). Halaman 266, 305.

Lachman, L., Lieberman, H.A., & J. L. Kanig. 1989b. Teori dan Praktek Farmasi Industri Jilid 2. Diterjemahkan oleh Siti Suyatmi. Jakarta : Penerbit UI Press.

Lawless, J. 2002. Encyclopedia of Essential Oils. London: Thorson. 226 p.

Loh, SW.,Awang, RM., Omar, D, & Rahmani, M. 2011. Insecticidal properties of Citrus hystrix DC leaves essential oil against Spodoptera litura fabricius. Journal of Medicinal Plants Research Vol. 5(16), pp. 3739-3744.

Longshore,Sharon J. RPH,MD., & Hollandsworth, Kimberly MD. 2003. Acne Vulgaris : One Treatment Does Not fit All. Cleveland Clinic Journal Of Medicine,Volume 70 Number 8. Cleveland.

Luangnarumitchai, S., Lamlertthon, S., & Tiyaboonchai, S. 2007. Antimicrobial Activity of Essential Oils Against Five Strains of Propionibacterium acnes. Mahidol University Journal of Pharmaceutical Sciences, Volume 34(1-4), 60-64.

Rowe, R.C., Sheskey, P.J., & Owen, S.C. 2009. Handbook of Pharmaceutical Excipient. Online Database. London: Pharmaceutical Press and American Pharmaceutical Association.

Sanna, V, Alessandra T,P, & Mario D,L. 2009. Effect of Vehicle on Diclofenac Sodium Permeation From New Formulations : In vitro and in vivo studies Current Drug Delivery, Vol.6, No.1.

Suardi, M., Armenia., & Maryawati, A. 2008. Formulasi dan Uji Klinik Gel Anti Jerawat Benzoil Peroksida-HPMC. Fakultas Farmasi FMIPA UNAND.

Sudjana. 1996. Metode Statistika. Halaman 22-29. Bandung : PT. Tarsito Bandung.

Voight, R. 1995. Buku Pelajaran Teknologi Farmasi. Yogyakarta : Gadjah Mada University Press.

Wyatt, E., Sutter, S.H., & Drake, L.A. 2001. Dermatologi Pharmacology, in Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Hardman, J.G., Limbird, L.E., Gilman, A.G., (Editor), 10th edition, 1801-1803. McGraw-Hill: New York.


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